Results 91 to 100 of about 3,071,489 (287)

Cost-effectiveness of infant vaccination with RIX4414 (Rotarix) in the UK.

, 2009
This study estimated the cost-effectiveness of infant rotavirus vaccination with Rotarix in the UK, taking into account community rotavirus infections that do not present to the healthcare system.
Batty, A, Martin, A, Roberts, JA, Standaert, B   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Assessing the disease burden of Yi people by years of life lost in Shilin county of Yunnan province, China [PDF]

, 2009
Background Years of Life Lost (YLL) is one of the methods used to estimate the duration of time lost due to premature death. While previous studies of disease burden have been reported using YLL, there have been no studies investigating YLL of Yi people ...
Shang-Cheng Zhou, Le Cai, Chong-Hua Wan, Yi-Ling Lv, Peng-Qian Fang, National Bureau of Statistics of China, ZL Yang, Le Cai, Cai Le, Yunnan Province Statistical Bureau, Cai Le, Y Jin, DT Jamison, CJL Murray, CJL Murray, CJL Murray, CJL Murray, CJL Murray, CJL Murray, A Coale, WHO, BM Ha, D Gunnell, SY Wang, A Hazen, Z Wang, A Sintuvanich, Y Li, S Mariotti, MC Michaud, MJ Indrayan, G Yang, AA Hyder   +32 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Trends and disparities in tuberculosis burden in Kazakhstan and Mongolia (2017–2021): a comparative analysis using GBD metrics

Frontiers in Public Health
BackgroundIn Central Asia, respiratory diseases, particularly tuberculosis (TB), are widespread communicable diseases that significantly impact both individuals and health systems, posing a substantial burden.
Oyunzul Amartsengel, Malika Idayat, Alexander Rommel, Natalya Glushkova, Kairat Davletov, Malik Adenov, Naranzul Dambaa, Lkhagvasuren Khorolsuren, Elena von der Lippe   +8 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

An integrated approach to cause-of-death analysis: cause-deleted life tables and decompositions of life expectancy [PDF]

This article integrates two methods that analyze the implications of various causes of death for life expectancy. One of the methods attributes changes in life expectancy to various causes of death; the other method examines the effect of removing deaths
Hiram Beltran-Sanchez, Samuel Preston, Vladimir Canudas-Romo   +2 more
core  

Health effects of adopting low greenhouse gas emission diets in the UK. [PDF]

, 2015
OBJECTIVE: Dietary changes which improve health are also likely to be beneficial for the environment by reducing emissions of greenhouse gases (GHG). However, previous analyses have not accounted for the potential acceptability of low GHG diets to the ...
Chalabi, Zaid, Dangour, Alan D, Green, Rosemary, Haines, Andy, Markandya, Anil, Milner, James, Spadaro, Joseph, Wilkinson, Paul   +7 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Economic Impact of Hyperhomocysteinemia in Switzerland [PDF]

, 2018
Summary: Since more than 20 years elevated homocysteine plasma levels have been associated with an elevated cardiovascular risk. It can be assumed that approx. 5-7% of the Swiss population suffers from hyperhomocysteinemia.
Käser, Andreas, Riesen, Walter, Szucs, Thomas   +2 more
core