Results 121 to 130 of about 1,379,653 (337)

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

open access: yesAdvanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang   +25 more
wiley   +1 more source

Engineering Bacterial Secretion Systems for Enhanced Tumor Imaging and Surgical Guidance

open access: yesAdvanced Materials, EarlyView.
This study presents a novel contrast agent platform, Streptavidin Associated Salmonella (SAS), for fluorescence image guided surgery. SAS selectively colonizes tumors and secretes streptavidin, enabling precise delineation of invasive tumor margins with prolonged signal retention.
Dohee Lee   +14 more
wiley   +1 more source

Flippase‐Mediated Hybrid Vesicle Division

open access: yesAdvanced Materials, EarlyView.
The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′‐triphosphate consumption and flipping of 2‐dioleoyl‐sn‐glycero‐3‐phospho‐l‐serine lipids from the inner to the outer leaflet.
Paula De Dios Andres   +5 more
wiley   +1 more source

Edge usage, motifs and regulatory logic for cell cycling genetic networks

open access: yes, 2013
The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A.   +2 more
core   +3 more sources

Autotrophic yeast

open access: yesNature Communications
Yeast is a widely used cell factory for the conversion of sugar into fuels, chemicals and pharmaceuticals. Establishing yeast as being autotrophic can enable it to grow solely on CO(2) and light, and hereby yeast can be used as a wider platform for transition to a sustainable society.
openaire   +3 more sources

Rational Development of a Novel Emulgel Adjuvant for Single‐Shot Effective Vaccination: A Multivariate Analysis Approach

open access: yesAdvanced Materials, EarlyView.
Using multivariate analysis, a novel emulgel adjuvant is developed by combining key nanoemulsion formulation variables–hydrogel trapping, small globule size, and mannide monooleate surfactant–achieving 10× greater immunogenicity than MF59 in mice after a single shot.
Ahmed O. Shalash   +9 more
wiley   +1 more source

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