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Fission Yeast Autophagy Machinery
Autophagy is a conserved process that delivers cytoplasmic components to the vacuole/lysosome. It plays important roles in maintaining cellular homeostasis and conferring stress resistance.
Dan-Dan Xu, Li-Lin Du
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Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures [PDF]
Living organisms have thermal limits above which they are unable to operate and survive. Our previous genetic screen identified proteins that impede the high-temperature growth of fission yeast, including the RNA-binding protein Dri1 and a fission yeast ...
Yutaka Akikusa +10 more
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3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast.
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family. It induces apoptosis and autophagy in some types of human cancer. DIM extends lifespan in the fission yeast Schizosaccharomyces pombe.
Parvaneh Emami, Masaru Ueno
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Cell-cycle analysis of fission yeast cells by flow cytometry. [PDF]
The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G(1) and G(2) phase contain the same amount of DNA.
Jon Halvor Jonsrud Knutsen +5 more
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Resveratrol modulates mitochondria dynamics in replicative senescent yeast cells. [PDF]
Mitochondria form a reticulum network dynamically fuse and divide in the cell. The balance between mitochondria fusion and fission is correlated to the shape, activity and integrity of these pivotal organelles.
I-Hua Wang +5 more
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BiFCo: visualizing cohesin assembly/disassembly cycle in living cells
A novel strategy developed in fission yeast to visualise only-assembled cohesin complex loading/unloading cycles in eukaryotic chromosomes in living cells. Cohesin is a highly conserved, ring-shaped protein complex found in all eukaryotes. It consists of
Emilio González-Martín +2 more
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Mitogen activated protein kinase (MAPK) signaling pathways execute essential functions in eukaryotic organisms by transducing extracellular stimuli into adaptive cellular responses.
Elisa Gómez-Gil +8 more
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Bioinformatical dissection of fission yeast DNA replication origins [PDF]
Replication origins in eukaryotes form a base for assembly of the pre-replication complex (pre-RC), thereby serving as an initiation site of DNA replication. Characteristics of replication origin vary among species.
Koji Masuda +3 more
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HIV-1 Protease in the Fission Yeast Schizosaccharomyces pombe. [PDF]
BACKGROUND:HIV-1 protease (PR) is an essential viral enzyme. Its primary function is to proteolyze the viral Gag-Pol polyprotein for production of viral enzymes and structural proteins and for maturation of infectious viral particles. Increasing evidence
Zsigmond Benko +4 more
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Global analysis of fission yeast mating genes reveals new autophagy factors. [PDF]
Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in animal development and human diseases. Molecular understanding of autophagy has mainly come from the budding yeast Saccharomyces cerevisiae, and it ...
Ling-Ling Sun +8 more
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