Results 41 to 50 of about 34,741 (182)

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

A comparative analysis of telomere length maintenance circuits in fission and budding yeast

Frontiers in Genetics, 2022
The natural ends of the linear eukaryotic chromosomes are protected by telomeres, which also play an important role in aging and cancer development. Telomere length varies between species, but it is strictly controlled in all organisms.
Iftah Peretz, Martin Kupiec, Roded Sharan   +2 more
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Analysis of DNA Metabolism in Fission Yeast [PDF]

Cold Spring Harbor Protocols, 2017
The fission yeast Schizosaccharomyces pombe is an excellent model organism to study DNA metabolism, in which the DNA replication and repair mechanisms are evolutionarily conserved. In this introduction we describe a range of methods commonly used to study aspects of DNA metabolism in fission yeast, focusing on approaches used for the analysis of genome
Antequera, Francisco, Humphrey, Timothy C.   +1 more
openaire   +3 more sources

Engineering and Characterization of a Fluorescent Fission Yeast Arp2/3 Complex for Single Molecule Mechanistic Investigations

Cytoskeleton, EarlyView.
ABSTRACT Arp2/3 complex is a seven‐component protein complex that facilitates the assembly of branched actin filament networks by binding to pre‐existing “mother” actin filaments and initiating the nucleation of new branched “daughter” filaments. Arp2/3 complex must be activated by a nucleation promoting factor such as the WASP/Scar protein family. The
Caitlin A. Anderson, Meghan E. O'Connell, Kaitlin E. Homa, Cristian Suarez, Michael L. James, Kashmeera D. Baboolall, Vilmos Zsolnay, Vladimir Sirotkin, David R. Kovar   +8 more
wiley   +1 more source

Fitness Landscape of the Fission Yeast Genome [PDF]

Molecular Biology and Evolution, 2018
Abstract Background Non-protein-coding regions of eukaryotic genomes remain poorly understood. Diversity studies, comparative genomics and biochemical outputs of genomic sites can be indicators of functional elements, but none produce fine-scale genome-wide descriptions of all functional elements.
Grech, Leanne, Jeffares, Daniel Charlton, Sadée, Christoph Yves, Rodríguez-López, María, Bitton, Danny Asher, Hoti, Mimoza, Biagosch, Carolina, Aravani, Dimitra, Speekenbrink, Maarten, Illingworth, Christopher J. R., Schiffer, Philipp H., Pidoux, Alison L., Tong, Pin, Tallada, Victor A., Allshire, Robin, Levin, Henry L., Bähler, Jürg   +16 more
openaire   +8 more sources

Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts

Microbial Cell
The role of model organisms such as yeasts in life science research is crucial. Although the baker’s yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the contribution of the fission yeasts (Schizosaccharomyces) to life science is ...
Lajos Acs-Szabo, Laszlo Attila Papp, Ida Miklos   +2 more
doaj   +1 more source

Comparative Research: Regulatory Mechanisms of Ribosomal Gene Transcription in Saccharomyces cerevisiae and Schizosaccharomyces pombe

Biomolecules, 2023
Restricting ribosome biosynthesis and assembly in response to nutrient starvation is a universal phenomenon that enables cells to survive with limited intracellular resources.
Hayato Hirai, Kunihiro Ohta
doaj   +1 more source

Domesticated bacterial origin genes regulate homeostasis of the insect gut microbiome and empower adaptation

iMeta, EarlyView.
Horizontal gene transfer introduced bacterial CDC genes into the leafhopper genome, providing genetic material for subsequent evolutionary innovation. Different CDC copies diversified at the sequence, structural, and functional levels. RdCDC3 retained its ancestral pore‐forming activity and was recruited for egg defense, whereas RdCDC9 lost its ...
Zhenjia Zhang, Yubo Zhang, Kun Zhao, Guangyuan Cheng, Zhihao Lu, Dongju Wang, Yiqun Liu, Jianguo Wu, Liying Wang, Lisheng Zhang, Xinhai Ye, Li Yu, Wei Zhang, Yi Li   +13 more
wiley   +1 more source

Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.

PLoS Genetics, 2007
The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated.
Araceli G Castillo, Barbara G Mellone, Janet F Partridge, William Richardson, Georgina L Hamilton, Robin C Allshire, Alison L Pidoux   +6 more
doaj   +1 more source