Results 21 to 30 of about 76,221 (224)
A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast.
PLoS Genetics, 2007 Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends.
Gareth A Cromie +5 more
doaj +1 more source
Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4. [PDF]
PLoS Genetics, 2007 The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated.
Araceli G Castillo +6 more
doaj +1 more source
Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells
Open Biology, 2023 The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
doaj +1 more source
Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination [PDF]
, 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original ...
Lorenz, Alexander +3 more
core +1 more source
Fission yeast goes synthetic [PDF]
Nature Methods, 2007 A high-throughput procedure for genome-wide identification of genetic interactions in Schizosaccharomyces pombe.
openaire +2 more sources
A Cloning-Free Method for CRISPR/Cas9-Mediated Genome Editing in Fission Yeast
G3: Genes, Genomes, Genetics, 2018 The CRISPR/Cas9 system, which relies on RNA‐guided DNA cleavage to induce site-specific DNA double-strand breaks, is a powerful tool for genome editing.
Xiao-Ran Zhang +3 more
doaj +1 more source
Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly [PDF]
Open Biology, 2014 CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast.
Lakxmi Subramanian +3 more
doaj +1 more source
eLife, 2021 Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation.
Tomoyuki Fukuda +9 more
doaj +1 more source
Basic methods for fission yeast [PDF]
Yeast, 2006 AbstractThe fission yeast Schizosaccharomyces pombe is a popular model system, and has been particularly influential in studies of the cell cycle and chromosome dynamics. Despite its differences from Saccharomyces cerevisiae, the tools and methods for fission yeast are conceptually similar to those used in budding yeast.
Susan L, Forsburg, Nicholas, Rhind
openaire +2 more sources
Dss1 is a 26S proteasome ubiquitin receptor [PDF]
, 2014 The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Arrigoni +35 more
core +5 more sources