Results 11 to 20 of about 34,244 (147)
eLife, 2019 Conserved proteins drive clathrin-mediated endocytosis (CME), which from yeast to humans involves a burst of actin assembly. To gain mechanistic insights into this process, we performed a side-by-side quantitative comparison of CME in two distantly ...
Yidi Sun +7 more
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Parkinson's Disease, 2011 In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its ...
Michael Fiske +8 more
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A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast.
PLoS Genetics, 2007 Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends.
Gareth A Cromie +5 more
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Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly [PDF]
Open Biology, 2014 CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast.
Lakxmi Subramanian +3 more
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Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4. [PDF]
PLoS Genetics, 2007 The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated.
Araceli G Castillo +6 more
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Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells
Open Biology, 2023 The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
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Communicative & Integrative Biology, 2016 In animal cells cytokinesis relies on the contraction of an actomyosin ring that pulls the plasma membrane to create a cleavage furrow, whose ingression finally divides the mother cell into two daughter cells.
Juan C. G. Cortés +4 more
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A Cloning-Free Method for CRISPR/Cas9-Mediated Genome Editing in Fission Yeast
G3: Genes, Genomes, Genetics, 2018 The CRISPR/Cas9 system, which relies on RNA‐guided DNA cleavage to induce site-specific DNA double-strand breaks, is a powerful tool for genome editing.
Xiao-Ran Zhang +3 more
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eLife, 2021 Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation.
Tomoyuki Fukuda +9 more
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Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP*
Journal of Lipid Research, 2008 The endoplasmic reticulum membrane protein SREBP cleavage-activating protein (Scap) senses sterols and regulates activation of sterol-regulatory element binding proteins (SREBPs), membrane-bound transcription factors that control lipid homeostasis in ...
Adam L. Hughes +2 more
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