Results 81 to 90 of about 1,258,398 (362)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Per aspera ad astra: When harmful chromosomal translocations become a plus value in genetic evolution. Lessons from Saccharomyces cerevisiae

open access: yesMicrobial Cell, 2015
In this review we will focus on chromosomal translocations (either spontaneous or induced) in budding yeast. Indeed, very few organisms tolerate so well aneuploidy like Saccharomyces, allowing in depth studies on chromosomal numerical ...
Valentina Tosato, Carlo V. Bruschi
doaj   +1 more source

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

open access: yesFEBS Open Bio, EarlyView.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques   +5 more
wiley   +1 more source

Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes

open access: yesMicrobial Cell, 2020
Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human genetic ...
Tiziana Cervelli   +3 more
doaj   +1 more source

The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised

open access: yesJournal of Fungi, 2021
Mtl1protein is a cell wall receptor belonging to the CWI pathway. Mtl1 function is related to glucose and oxidative stress signaling. In this report, we show data demonstrating that Mtl1 plays a critical role in the detection of a descent in glucose ...
Sandra Montella-Manuel   +2 more
doaj   +1 more source

Studies of unicellular micro-organisms Saccharomyces cerevisiae by means of Positron Annihilation Lifetime Spectroscopy [PDF]

open access: yesNukleonika 60(4) (2015) 749-753, 2015
Results of Positron Annihilation Lifetime Spectroscopy (PALS) and microscopic studies on simple microorganisms: brewing yeasts are presented. Lifetime of ortho - positronium (o-Ps) were found to change from 2.4 to 2.9 ns (longer lived component) for lyophilised and aqueous yeasts, respectively.
arxiv   +1 more source

Warner’s Safe Cook Book [PDF]

open access: yes, 1887
Published by the H.H. Warner Company, a noted Rochester-based safe (and later patent medicine) manufacturing company, this large cookbook is teeming with hundreds of recipes for everything ranging from mustard pickles to pepper mangoes and venison pie ...
Warner\u27s Safe Yeast Company
core   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast

open access: yesCell Communication and Signaling, 2019
Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the calcium signalling pathway, the protein ...
Huihui Xu   +3 more
doaj   +1 more source

Factors affecting the activity of baker's compressed and active dry yeast : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Biotechnology at Massey University [PDF]

open access: yes, 1980
Factors affecting the Activity of Baker's Compressed and Active Dry Yeast. Parameters important in the production of Baker's Yeast were correlated with the product's final activity.
Espie, Stephen Angus
core  

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