Results 11 to 20 of about 845,439 (243)

Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells

open access: yesOpen Biology, 2023
The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
doaj   +1 more source

Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes

open access: yesMicrobial Cell, 2020
Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human genetic ...
Tiziana Cervelli   +3 more
doaj   +1 more source

Impact of particle size reduction on high gravity enzymatic hydrolysis of steam-exploded wheat straw

open access: yesSN Applied Sciences, 2021
Article Highlights Fiber size reduction benefits enzymatic high gravity hydrolysis of steam-exploded wheat straw. Small fiber size of ≤ 2.5 mm enables saccharification at 35% w/w solid loadings.
Luis Hoppert, Daniel Einfalt
doaj   +1 more source

Introducing a Simple Method to Investigate Relative Volatilities of Flavour Compounds in Fruit Brandies

open access: yesBeverages, 2023
Determination of relative volatilities of flavour compounds in hydro-alcoholic solutions is usually performed by time-consuming and costly standard methods such as the Gillespie dynamic recirculation method. This study tested a quick and easy method with
Manami Yagishita   +2 more
doaj   +1 more source

Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission Yeast Schizosaccharomyces japonicus

open access: yesJournal of Fungi, 2021
Mitogen activated protein kinase (MAPK) signaling pathways execute essential functions in eukaryotic organisms by transducing extracellular stimuli into adaptive cellular responses.
Elisa Gómez-Gil   +8 more
doaj   +1 more source

A Multiphase Multiobjective Dynamic Genome-Scale Model Shows Different Redox Balancing among Yeast Species of the Saccharomyces Genus in Fermentation

open access: yesmSystems, 2021
Nonconventional yeast species hold the promise to provide novel metabolic routes to produce industrially relevant compounds and tolerate specific stressors, such as cold temperatures.
David Henriques   +8 more
doaj   +3 more sources

Divergence of cytokinesis and dimorphism control by myosin II regulatory light chain in fission yeasts

open access: yesiScience, 2023
Summary: Non-muscle myosin II activation by regulatory light chain (Rlc1Sp) phosphorylation at Ser35 is crucial for cytokinesis during respiration in the fission yeast Schizosaccharomyces pombe.
Francisco Prieto-Ruiz   +6 more
doaj   +1 more source

The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond

open access: yesJournal of Fungi, 2021
The survival of eukaryotic organisms during environmental changes is largely dependent on the adaptive responses elicited by signal transduction cascades, including those regulated by the Mitogen-Activated Protein Kinase (MAPK) pathways.
José Cansado   +4 more
doaj   +1 more source

Timing of Chromosome DNA Integration throughout the Yeast Cell Cycle

open access: yesBiomolecules, 2023
The dynamic mechanism of cell uptake and genomic integration of exogenous linear DNA still has to be completely clarified, especially within each phase of the cell cycle.
Valentina Tosato   +3 more
doaj   +1 more source

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