Results 61 to 70 of about 613,719 (256)

Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1. [PDF]

PLoS Genetics, 2006
Sgs1, the budding yeast homolog of the mammalian BLM helicase, has been implicated in preventing excess recombination during both vegetative growth and meiosis.
Lea Jessop, Beth Rockmill, G Shirleen Roeder, Michael Lichten   +3 more
doaj   +1 more source

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis [PDF]

, 2013
Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits
Krejci, Lumir, Sebesta, Marek, Plault, Nicolas, Robert, Thomas, Burkovics, Péter, Marini, Victoria, Szukacsov, Valéria, Haracska, Lajos, Sisakova, Alexandra, Gangloff, Serge, Kolesar, Peter, Pintér, Lajos   +11 more
core   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Structure of the hDmc1-ssDNA filament reveals the principles of its architecture [PDF]

, 2010
In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes.
Dmitry V Bugreev, Julie Hodgkinson, Yuriy L Chaban, Bugreev, DV, Orlova, Elena, Orlova, EV, Hodgkinson, J.L., Orlova Elena V., Chaban, Y.L., Bugreev, D.V., Andrei L Okorokov, Chaban Yuriy L., Okorokov, AL, Elena V Orlova, Okorokov, A.L., Hodgkinson, J, Bugreev Dmitry V., Chaban, YL, Okorokov Andrei L., Mazin, AV, Hodgkinson Julie, Mazin, A.V., Alexander V Mazin, Mazin Alexander V.   +23 more
core   +2 more sources

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]

, 2013
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Lucy Glover (24966), Sam Alsford, David Horn (24969), Alsford, Sam, Lucy Glover, Sam Alsford (24967), David Horn   +9 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Recombination and Its Impact on the Genome of the Haplodiploid Parasitoid Wasp Nasonia [PDF]

, 2010
Homologous meiotic recombination occurs in most sexually reproducing organisms, yet its evolutionary advantages are elusive. Previous research explored recombination in the honeybee, a eusocial hymenopteran with an exceptionally high genome-wide ...
Gibson, Joshua D., Gadau Jürgen, Desjardins, Christopher A.,, Kennedy Kathleen, Beukeboom, Leo W.,, Koevoets Tosca, Kennedy, Kathleen,, Gibson Joshua D., Werren, John H., Gibson, Joshua D.,, Koevoets, Tosca, van de Zande, Louis, Gadau, Jürgen, Shuker David M., Niehuis, Oliver, Joshua D Gibson, Leo W Beukeboom, Judson, Andrea K.,, David M. Shuker, Andrea K Judson, Duggan, David,, David Duggan, Shuker, David M.,, Niehuis, Oliver,, David M Shuker, Beukeboom Leo W., van de Zande Louis, Christopher A Desjardins, Bart A. Pannebakker, Rosenberg, Michael S., Duggan, David, Kathleen Kennedy, Gadau, Jürgen,, Shuker, David Michael, Gadau, Juergen, van de Zande, Louis; id_orcid, Andrea K. Judson, John H Werren, Judson, Andrea K., Kennedy, Kathleen, Werren, John H.,, Pannebakker Bart A., Michael S. Rosenberg, Tosca Koevoets, Louis van de Zande, Beukeboom, Leo W., Werren John H., John H. Werren, Jürgen Gadau, Pannebakker, Bart A., Duggan David, Niehuis Oliver, Christopher A. Desjardins, Pannebakker, Bart A.,, Leo W. Beukeboom, Desjardins, Christopher A., Oliver Niehuis, Joshua D. Gibson, Rosenberg Michael S., Bart A Pannebakker, Michael S Rosenberg, Koevoets, Tosca,, Judson Andrea K., Zande, Louis van de,, Rosenberg, Michael S.,, Shuker, David M., Desjardins Christopher A.   +66 more
core   +3 more sources

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

Cell Reports, 2017
Summary: DNA double-strand break repair by homologous recombination entails the resection of DNA ends to reveal ssDNA tails, which are used to invade a homologous DNA template.
James M. Daley, Judit Jimenez-Sainz, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Ryan B. Jensen, Patrick Sung   +7 more
doaj   +1 more source

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
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