Results 31 to 40 of about 187,476 (281)

Implications of the Actin Cytoskeleton on the Multi-Step Process of [PSI⁺] Prion Formation

Viruses, 2022
Yeast prions are self-perpetuating misfolded proteins that are infectious. In yeast, [PSI+] is the prion form of the Sup35 protein. While the study of [PSI+] has revealed important cellular mechanisms that contribute to prion propagation, the underlying ...
Jane E. Dorweiler, Douglas R. Lyke, Nathan P. Lemoine, Samantha Guereca, Hannah E. Buchholz, Emily R. Legan, Claire M. Radtke, Anita L. Manogaran   +7 more
doaj   +1 more source

Yeast Particle Encapsulation of Azole Fungicides for Enhanced Treatment of Azole-Resistant Candida albicans

Journal of Functional Biomaterials
Addressing the growing problem of antifungal resistance in medicine and agriculture requires the development of new drugs and strategies to preserve the efficacy of existing fungicides. One approach is to utilize delivery technologies.
Ernesto R. Soto, Florentina Rus, Gary R. Ostroff   +2 more
doaj   +1 more source

The physical dimensions of amyloid aggregates control their infective potential as prion particles

eLife, 2017
Transmissible amyloid particles called prions are associated with infectious prion diseases in mammals and inherited phenotypes in yeast. All amyloid aggregates can give rise to potentially infectious seeds that accelerate their growth.
Ricardo Marchante, David M Beal, Nadejda Koloteva-Levine, Tracey J Purton, Mick F Tuite, Wei-Feng Xue   +5 more
doaj   +1 more source

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]

, 2019
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide, Bard, Bard, Bard, Bashore, Beckwith, Dambacher, de la Peña, Ding, Dong, Eisele, Elsasser, Finley, Glickman, Glickman, Goldstein, Groll, Hershko, Kachroo, Lander, Lasker, Longtine, Matyskiela, Myers, Nemec, Peth, Prakash, Rubin, Smith, Sone, Tomko, Unverdorben, Verma, VerPlank, VerPlank, Wehmer, Wendler, Wenzel, Worden, Worden, Yao, Zhu, Śledź   +42 more
core   +1 more source

The comparison of genetic instability in haploid and diploid yeast cells exposed to ionizing radiations of different linear energy transfer and ultraviolet light

Journal of Radiation and Cancer Research, 2018
Context: It is analyzed whether genetic instability is determined by cell ability to recover from radiation damage or it is mainly determined by cell ploidy.
Ekaterina S Evstratova, Kaushala P Mishra, Vladislav G Petin   +2 more
doaj   +1 more source

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]

, 1994
To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV, Paddy, MR, Swanson, MS, Swedlow, JR, Wilson, SM   +4 more
core   +1 more source

Coagulation-fragmentation for a finite number of particles and application to telomere clustering in the yeast nucleus

, 2012
We develop a coagulation-fragmentation model to study a system composed of a small number of stochastic objects moving in a confined domain, that can aggregate upon binding to form local clusters of arbitrary sizes. A cluster can also dissociate into two
Holcman, David, Hoze, Nathanael
core   +1 more source

cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins [PDF]

, 2008
mRNA localization is a conserved post-transcriptional process crucial for a variety of systems. Although several mechanisms have been identified, emerging evidence suggests that most transcripts reach the protein functional site by moving along ...
AMORESANO, ANGELA, C. Cirulli, PIETROPAOLO, CONCETTA, PUCCI, PIETRO, RUSSO, ANNAPINA, RUSSO, GIULIA   +5 more
core   +1 more source

Preparation and Physicochemical Properties Analysis of Yeast β-Glucan Nanoparticles

Shipin gongye ke-ji
Yeast β-glucan was a multifunctional polysaccharide, but it was insoluble in water and present particles. To broaden its applicability, the yeast β-glucan nanoparticles were prepared by ball milling pulverization using yeast cells of Saccharomyces ...
Xiaohong HOU, Guoqun ZHAO, Jinlong LIU
doaj   +1 more source

Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast

Nature Communications, 2021
The molecular events underlying the assembly and maturation of the early pre-60S particles during eukaryotic ribosome synthesis are not well understood. Here, the authors combine yeast genetics and biochemical experiments to characterise the functions of
Mariam Jaafar, Julia Contreras, Carine Dominique, Sara Martín-Villanueva, Régine Capeyrou, Patrice Vitali, Olga Rodríguez-Galán, Carmen Velasco, Odile Humbert, Nicholas J. Watkins, Eduardo Villalobo, Katherine E. Bohnsack, Markus T. Bohnsack, Yves Henry, Raghida Abou Merhi, Jesús de la Cruz, Anthony K. Henras   +16 more
doaj   +1 more source