Results 291 to 300 of about 356,347 (342)

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

open access: yesAngewandte Chemie, EarlyView.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur   +11 more
wiley   +1 more source

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

open access: yesAngewandte Chemie, EarlyView.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar   +15 more
wiley   +1 more source

Metabolic Engineering of the 5‐Aminolevulinate Biosynthetic Pathway in E. coli Improves Efficiency of Hemoprotein‐Based Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
We have engineered the heme biosynthetic pathway in E. coli to develop an efficient cofactor supplementation system for hemoproteins. Through the incorporation of the heterogeneous C4 pathway, the engineered cells significantly increase the expression levels of active holohemoproteins and enhance the efficiency of whole‐cell and lysate‐based ...
Shunsuke Kato   +6 more
wiley   +1 more source

Evaluation of Satanin 1 as a potential antifungal antimicrobial peptide to treat Malassezia infections. [PDF]

open access: yesSci Rep
Molina Pineda JS   +5 more
europepmc   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

open access: yesAngewandte Chemie International Edition, EarlyView.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer   +4 more
wiley   +1 more source

Microbial succession and interaction in vacuum-packed beef: a longitudinal study of bacterial and fungal dynamics. [PDF]

open access: yesNPJ Sci Food
Roch FF   +6 more
europepmc   +1 more source

Brown locusts, Locustana pardalina, host fluconazole resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains. [PDF]

open access: yesMed Mycol
Ogundeji A   +12 more
europepmc   +1 more source

Photo Quiz: A cutaneous fungal infection with discordant biomarker results-a diagnostic challenge. [PDF]

open access: yesJ Clin Microbiol
Dumont G   +7 more
europepmc   +1 more source

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