Results 211 to 220 of about 1,592,983 (303)

Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis. [PDF]

Biomolecules, 2023
Taiyab A, Belahlou Y, Wong V, Pandi S, Shekhar M, Chidambaranathan GP, West-Mays J.   +6 more
europepmc   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Editor's Note: Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC. [PDF]

J Natl Cancer Inst
europepmc   +1 more source

Sentrin/SUMO-specific protease 1 contributes to drug resistance in melanoma by mediating the deSUMOylation of Yes-associated protein. [PDF]

Postepy Dermatol Alergol
Zhao B, Liu Y, Tang X, Cheng S.
europepmc   +1 more source

Alcohol Consumption Is a Risk Factor of Surgical Site Infection After Minimally Invasive Surgery: A Secondary Observational Analysis of a Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
Alcohol consumption was independently associated with Surgical Site Infection in the gastroenterological Minimally Invasive Surgery. Whether preoperative abstinence from alcohol prevents the occurrence of SSI warrants further investigation. ABSTRACT Background Surgical site infection (SSI) is one of the postoperative complications. Risk factors for SSI
Toshiya Akai, Makoto Takeda, Eisuke Booka, Tomohiro Matsumoto, Masayo Takaoka, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi   +9 more
wiley   +1 more source

Targeting the Hippo Pathway in Breast Cancer: A Proteomic Analysis of Yes-Associated Protein Inhibition. [PDF]

Int J Mol Sci
Yanar S, Bal Albayrak MG, Korak T, Deveci Ozkan A, Arabacı Tamer S, Kasap M.   +5 more
europepmc   +1 more source

Can Machine Learning Reduce Unnecessary Surgeries? A Retrospective Analysis Using Threshold Optimization to Prevent Negative Appendectomies in Adults

Annals of Gastroenterological Surgery, EarlyView.
Threshold‐optimized machine learning models using routine clinical and laboratory data in 623 adults undergoing appendectomy. Logistic regression (AUC = 0.765) and random forest (AUC = 0.785) were the best‐performing models for appendicitis detection and complicated appendicitis prediction, respectively.
Ivan Males, Marko Kumric, Zvonimir Boban, Josip Vrdoljak, Dario Pecenkovic, Matej Ivanda, Marko Grahovac, Zenon Pogorelic, Josko Bozic   +8 more
wiley   +1 more source

Dopamine receptor D1-mediated suppression of liver fibrosis <i>via</i> Hippo/Yes-associated protein 1 signaling in levodopa treatment. [PDF]

World J Gastroenterol
Wang HY, Qi MM, Zhang K, Zhu YZ, Zhang J.   +4 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Depleting Yes-Associated Protein in Gli1-Expressing Cells Attenuates Peritoneal Dialysis-Induced Peritoneal Fibrosis. [PDF]

J Cell Mol Med
Wu CL, Hsu JW, Chan YC, Yu JY, Tsai YL, Tarng DC.   +5 more
europepmc   +1 more source