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YidC as a potential antibiotic target

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023
The membrane insertase YidC, is an essential bacterial component and functions in the folding and insertion of many membrane proteins during their biogenesis. It is a multispanning protein in the inner (cytoplasmic) membrane of Escherichia coli that binds its substrates in the "greasy slide" through hydrophobic interaction.
Ross E, Dalbey   +2 more
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YidC mediates membrane protein insertion in bacteria

Nature, 2000
The basic machinery for the translocation of proteins into or across membranes is remarkably conserved from Escherichia coli to humans. In eukaryotes, proteins are inserted into the endoplasmic reticulum using the signal recognition particle (SRP) and the SRP receptor, as well as the integral membrane Sec61 trimeric complex (composed of alpha, beta and
J C, Samuelson   +7 more
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Structure of YidC from Thermotoga maritima and its implications for YidC‐mediated membrane protein insertion

The FASEB Journal, 2018
The evolutionarily conserved YidC/Oxa1/Alb3 family of proteins represents a unique membrane protein family that facilitates the insertion, folding, and assembly of a cohort of α‐helical membrane proteins in all kingdoms of life, yet its underlying mechanisms remain elusive. We report the crystal structures of the full‐length
Yanlong, Xin   +6 more
openaire   +2 more sources

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