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How YidC inserts and folds proteins across a membrane
Nature Structural & Molecular Biology, 2014The crystal structure of the membrane insertase YidC reveals a hydrophilic groove in the cytoplasmic bilayer leaflet, suggesting a new mechanism of membrane-protein insertion.
Ross E, Dalbey, Andreas, Kuhn
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YidC-Driven Membrane Insertion of Single Fluorescent Pf3 Coat Proteins
Journal of Molecular Biology, 2011The membrane insertion of single bacteriophage Pf3 coat proteins was observed by confocal fluorescence microscopy. Within seconds after addition of the purified and fluorescently labeled protein to liposomes or proteoliposomes containing the purified and reconstituted membrane insertase YidC of Escherichia coli, the translocation of the labeled residue
Stefan, Ernst +4 more
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From the Sec complex to the membrane insertase YidC
bchm, 2009Abstract The key enzymes that catalyze the insertion of proteins into membranes are the Sec translocase and the YidC membrane insertase. Recent insights into the structure and functional intermediates of these enzymes have provided a first molecular glimpse of how they help the newly synthesized proteins to enter the membrane bilayer. In
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Projection Structure of yidC: A Conserved Mediator of Membrane Protein Assembly
Journal of Molecular Biology, 2008Bacteria, mitochondria and chloroplasts harbour factors that facilitate the insertion, folding and assembly of membrane proteins. In Escherichia coli, yidC is required for membrane insertion, acting in both a Sec-dependent and a Sec-independent manner. There is an expanding volume of biochemical work on its role in this process, but none so far on its ...
Lotz, M +3 more
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M13 Procoat Protein Insertion into YidC and SecYEG Proteoliposomes and Liposomes
Journal of Molecular Biology, 2011M13 procoat protein was one of the first model proteins used to study bacterial membrane protein insertion. It contains a signal peptide of 23 amino acid residues and is not membrane targeted by the signal recognition particle. The translocation of its periplasmic domain is independent of the preprotein translocase (SecAYEG) but requires ...
Natalie, Stiegler +2 more
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YidC as an Essential and Multifunctional Component in Membrane Protein Assembly
2007Membrane proteins fulfill a number of vital functions in prokaryotic and eukaryotic cells. They are often organized in multicomponent complexes, folded within the membrane bilayer and interacting with the cytoplasmic and periplasmic or external soluble compartments.
Dorothee, Kiefer, Andreas, Kuhn
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Faculty Opinions recommendation of YidC-mediated membrane insertion.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019openaire +1 more source