Results 31 to 40 of about 3,619 (189)
A structural model of the active ribosome-bound membrane protein insertase YidC
eLife, 2014 The integration of most membrane proteins into the cytoplasmic membrane of bacteria occurs co-translationally. The universally conserved YidC protein mediates this process either individually as a membrane protein insertase, or in concert with the SecY ...
Stephan Wickles +9 more
doaj +1 more source
Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC [PDF]
, 2016 Protein secretion and membrane insertion occur through the ubiquitous Sec machinery. In this system, insertion involves the targeting of translating ribosomes via the signal recognition particle and its cognate receptor to the SecY (bacteria and archaea)/
Alvira-de-Celis, Sara +10 more
core +4 more sources
Structural Requirements of a Glycolipid MPIase for Membrane Protein Integration
Chemistry – A European Journal, Volume 29, Issue 30, May 26, 2023., 2023 MPIase, a glycolipid, is involved in membrane protein integration in the inner membrane of Escherichia coli. In this study, we synthesized analogs to reveal the structural requirements and glycan‐length dependency for the integration and chaperone‐like activity, and synergistic effects with the membrane chaperone, YidC.
Kohki Fujikawa +7 more
wiley +1 more source
Role of YidC in folding of polytopic membrane proteins [PDF]
The Journal of Cell Biology, 2004 YidC of Echerichia coli, a member of the conserved Alb3/Oxa1/YidC family, is postulated to be important for biogenesis of membrane proteins. Here, we use as a model the lactose permease (LacY), a membrane transport protein with a known three-dimensional structure, to determine whether YidC plays a role in polytopic membrane protein insertion and/or ...
Nagamori, Shushi +2 more
openaire +4 more sources
mBio, 2011 Membrane proteins are involved in numerous essential cell processes, including transport, gene regulation, motility, and metabolism. To function properly, they must be inserted into the membrane and folded correctly.
Andrew N. Gray +5 more
doaj +1 more source
Frontiers in Microbiology, 2021 Integral and membrane-anchored proteins are pivotal to survival and virulence of the dental pathogen, Streptococcus mutans. The bacterial chaperone/insertase, YidC, contributes to membrane protein translocation.
Surabhi Mishra, L. Jeannine Brady
doaj +1 more source
The integration of YidC into the cytoplasmic membrane of Escherichia coli requires the signal recognition particle, SecA and SecYEG [PDF]
, 2002 The integration of the polytopic membrane protein YidC into the inner membrane of Escherichia coli was analyzed employing an in vitro system. Upon integration of in vitro synthesized YidC, a 42-kDa membrane protected fragment was detected, which could be
Koch, H. G. +3 more
core +2 more sources
Molecular Microbiology, Volume 119, Issue 5, Page 537-550, May 2023., 2023 The trypanosomal orthologue of the mitoribosome receptor Mba1 (TbMba1) is essential for normal growth of procyclic trypanosomes. Proteomic analyses of TbMba1‐depleted mitochondria revealed reduced levels of many components of the cytochrome c oxidase (Cox) complex, three subunits of which are mitochondrially encoded.
Christoph Wenger +7 more
wiley +1 more source
The ER membrane complex (EMC) can functionally replace the Oxa1 insertase in mitochondria
PLoS Biology, 2022 Two multisubunit protein complexes for membrane protein insertion were recently identified in the endoplasmic reticulum (ER): the guided entry of tail anchor proteins (GET) complex and ER membrane complex (EMC).
Büsra Güngör +3 more
doaj +2 more sources
Flavour physics without flavour symmetries [PDF]
, 2017 We quantitatively analyze a quark-lepton flavour model derived from a six-dimensional supersymmetric theory with $SO(10)\times U(1)$ gauge symmetry, compactified on an orbifold with magnetic flux.
Buchmuller, Wilfried, Patel, Ketan M.
core +2 more sources