Results 81 to 90 of about 3,619 (189)

OXA1L deficiency causes mitochondrial myopathy via reactive oxygen species regulated nuclear factor kappa B signalling pathway

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
OXA1L gene bi‐allelic variants cause mitochondrial myopathy. OXA1L deficiency results in combined mitochondrial respiratory chain defects and OXPHOS impairments. OXA1L deficiency leads to elevated ROS production, which may activate the NF‐κB signalling pathway, disturbing myogenic gene expression and triggering cell apoptosis. Abstract Background OXA1L
Yongkun Zhan, Qian Wang, Ya Wang, Yanjie Fan, Dan Yan, Xianlong Lin, Yaoting Chen, Tingting Hu, Nan Li, Weiqian Dai, Hezhi Fang, Yongguo Yu   +11 more
wiley   +1 more source

The bacterial protein YidC accelerates MPIase-dependent integration of membrane proteins [PDF]

Journal of Biological Chemistry, 2019
Bacterial membrane proteins are integrated into membranes through the concerted activities of a series of integration factors, including membrane protein integrase (MPIase). However, how MPIase activity is complemented by other integration factors during membrane protein integration is incompletely understood.
Masaru Sasaki, Hanako Nishikawa, Sonomi Suzuki, Michael Moser, Maria Huber, Katsuhiro Sawasato, Hideaki T. Matsubayashi, Kaoru Kumazaki, Tomoya Tsukazaki, Yutetsu Kuruma, Osamu Nureki, Takuya Ueda, Ken-ichi Nishiyama   +12 more
openaire   +2 more sources

Heat Adaptation Induced Cross Protection Against Ethanol Stress in Tetragenococcus halophilus: Physiological Characteristics and Proteomic Analysis

Frontiers in Microbiology, 2021
Ethanol is a toxic factor that damages membranes, disturbs metabolism, and may kill the cell. Tetragenococcus halophilus, considered as the cell factory during the manufacture of traditional fermented foods, encounters ethanol stress, which may affect ...
Huan Yang, Huan Yang, Shangjie Yao, Shangjie Yao, Min Zhang, Min Zhang, Chongde Wu, Chongde Wu   +7 more
doaj   +1 more source

New insights into enterocin CRL35: mechanism of action and immunity revealed by heterologous expression in Escherichia coli [PDF]

, 2017
The role of the class IIa bacteriocin membrane receptor protein remains unclear, and the following two different mechanisms have been proposed: the bacteriocin could interact with the receptor changing it to an open conformation or the receptor might act
Acuña, Leonardo, Barraza, Daniela Estefanía, Bellomio, Augusto, Chalon, Miriam Carolina, Galván, Adriana Emilce, Minahk, Carlos Javier, Ríos Colombo, Natalia Soledad   +6 more
core   +1 more source

Strong Environmental and Genome‐Wide Population Differentiation Underpins Adaptation and High Genomic Vulnerability in the Dominant Australian Kelp (Ecklonia radiata)

Ecology and Evolution, Volume 15, Issue 5, May 2025.
The dominant Australian kelp, Ecklonia radiata, was genotyped from 10 locations spanning a 2000 km latitudinal gradient along the east coast of Australia using ddRAD sequencing. Strong genetic differentiation was found between mainland Australia and Tasmania, while adaptive SNP candidates identified local adaptation at the species' range edges with low
Antoine J. P. Minne, Sofie Vranken, David Wheeler, Georgina Wood, Jacqueline Batley, Thomas Wernberg, Melinda A. Coleman   +6 more
wiley   +1 more source

Multiprotein Complex Production in E. coli: The SecYEG-SecDFYajC-YidC Holotranslocon [PDF]

, 2017
A modular approach for balanced overexpression of recombinant multiprotein complexes in E. coli is described, with the prokaryotic protein secretase/insertase complex, the SecYEG-SecDFYajC-YidC holotranslocon (HTL), used as an example. This procedure has been implemented here in the ACEMBL system.
Berger, Imre, Jiang, Quiyang, Schulze, Ryan, Collinson, Ian, Schaffitzel, Christiane   +4 more
openaire   +4 more sources

In Silico Discovery of Novel Drug and Vaccine Targets in Chlamydia abortus Through Subtractive Genomics

The Iraqi Journal of Veterinary Medicine
Chlamydia abortus is a Gram-negative bacterium that causes chlamydiosis, a zoonotic disease leading to abortions and stillbirths in livestock and posing significant public health risks.
Zainab Oun Ali, Sura Al-Asadi, Batool Hazim Abdul Wahhab, Jamila Rampurawala   +3 more
doaj   +1 more source

Cotranslational Biogenesis of Membrane Proteins in Bacteria

Frontiers in Molecular Biosciences, 2022
Nascent polypeptides emerging from the ribosome during translation are rapidly scanned and processed by ribosome-associated protein biogenesis factors (RPBs). RPBs cleave the N-terminal formyl and methionine groups, assist cotranslational protein folding,
Evan Mercier, Xiaolin Wang, Lena A. K. Bögeholz, Wolfgang Wintermeyer, Marina V. Rodnina   +4 more
doaj   +1 more source

Mapping of the \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Oxa1-Mitochondrial Ribosome Interface and Identification of MrpL40, a Ribosomal Protein in Close Proximity to Oxa1 and Critical for Oxidative Phosphorylation Complex Assembly [PDF]

, 2009
The Oxa1 protein plays a central role in facilitating the cotranslational insertion of the nascent polypeptide chains into the mitochondrial inner membrane. Mitochondrially encoded proteins are synthesized on matrix-localized ribosomes which are tethered
Jia, Lixia, Kaur, Jasvinder, Stuart, Rosemary A.   +2 more
core   +1 more source

ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts [PDF]

, 2016
Multicomponent biological systems perform a wide variety of functions and are crucially important for a broad range of critical health and disease states.
A Basters, A Kriz, AB Rode, AJ Jakobi, B Geering, B Weiss, BM Olivera, C Bieniossek, C Bieniossek, C Romier, C Schaffitzel, CP Chou, CV Robinson, D Busso, D Sari, D Schelshorn, DG Gibson, DJ Pitera, DN Gopaul, F Guo, F Leinert, G Bartani, G Gosset, G Kellenberger, H Alper, H Ye, HO Smith, J Komar, J Quan, J Torella, JA Chemler, JH Park, K Ballmer-Hofer, KB Mullis, LF Estrozi, LR Jarboe, LS Vijayachandran, M Folcher, M Gellert, M Haffke, M Haffke, M Meselson, MCY Chang, ML Diebold, ML Gefter, MZ Li, N Zheng, NR Cozzarelli, O Loeffelholz Von, PE Nisson, PJA Cock, R Patnaik, R Vincentelli, RJ Schulze, S Ausländer, S Cunna, S Linn, S Trowitzsch, S Trowitzsch, SC Almo, SE Luria, SJ Berríos-Rivera, SK Lee, SY Lee, T Maniatis, TC Terwilliger, VC Bode, W Abdulrahman, W Weber, WW Metcalf, Y Nie, Y Zhang   +71 more
core   +3 more sources