Results 141 to 150 of about 6,883,757 (381)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Metabolic engineering of Escherichia coli for the production of 5-aminolevulinic acid based on combined metabolic pathway modification and reporter-guided mutant selection (RGMS)

Biotechnology for Biofuels and Bioproducts
Background 5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition and agriculture.
Yuting Yang, Yuhong Zou, Xi Chen, Haidong Sun, Xia Hua, Lee Johnston, Xiangfang Zeng, Shiyan Qiao, Changchuan Ye   +8 more
doaj   +1 more source

Building Software Engineering Capacity through a University Open Source Program Office [PDF]

arXiv
This work introduces an innovative program for training the next generation of software engineers within university settings, addressing the limitations of traditional software engineering courses. Initial program costs were significant, totaling $551,420 in direct expenditures to pay for program staff salaries and benefits over two years. We present a
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Cell Sheet Engineering in Periodontology: A Review [PDF]

Journal of Clinical and Diagnostic Research
Cell sheet engineering has developed its own place for the regeneration of tissues. It focuses on phenomena occurring at the cellular level, whereas regenerative medicine and tissue engineering aim to create or stimulate new tissue for the treatment of ...
Ruchita Tejrao Patil, Prasad V Dhadse, Shrishti Salian   +2 more
doaj   +1 more source

Testing as an Investment [PDF]

arXiv, 2017
Software testing is an expensive and important task. Plenty of researches and industrial efforts have been invested on improving software testing techniques, including criteria, tools, etc. These studies can provide guidelines to select suitable test techniques for software engineers.
arxiv  

Beating the blues: engineering cryptochrome expression improves soybean yield [PDF]

, 2021
Ronald Pierik
openalex   +1 more source

Fluids in cosmology

, 2013
We review the role of fluids in cosmology by first introducing them in General Relativity and then by applying them to a FRW Universe's model. We describe how relativistic and non-relativistic components evolve in the background dynamics.
A Albrecht, A Aviles, A Carnero, A Friedmann, A Friedmann, AA Penzias, AD Dolgov, AD Dolgov, AD Dolgov, AD Linde, AG Cohen, AG Riess, AG Riess, AG Walker, AH Guth, B Hoyle, BA Reid, BD Sherwin, BF Schutz, C Marinoni, CM Chambers, CP Ma, CP Ma, CW Misner, DH Lyth, DJ Eisenstein, DJ Eisenstein, DJ Eisenstein, DJ Fixsen, EJ Copeland, EP Hubble, EV Linder, EW Kolb, FL Bezrukov, G Gamow, G Gamow, G Mangano, G Steigman, GF Smoot, GFR Ellis, GW Gibbons, HB Richer, HJ Seo, HP Robertson, HP Robertson, HP Robertson, J Carlson, J De-Santiago, J Kim, J Magaña, JC Mather, JL Cervantes-Cota, JL Cervantes-Cota, JL Cervantes-Cota, JL Cervantes-Cota, JR Bond, JV Narlikar, L Amendola, L Anderson, L Kofman, L Kofman, LF Abbott, M Chevallier, M Trodden, M Zaldarriaga, MS Turner, N Jarosik, N Turok, P Bernardis, PJ Steinhardt, R Allahverdi, R Amanullah, R Jimenez, RH Cyburt, RR Caldwell, RR Caldwell, S Carrol, S Davidson, S Perlmutter, S Weinberg, S Weinberg, S Weinberg, SW Allen, T Giannantonio, T Matos, U Seljak, VF Mukhanov, W Hu, Y Aoki   +88 more
core   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source