Results 161 to 170 of about 4,436,723 (262)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Rethinking yield stability through phenotypic plasticity and its link to modern statistical methods. [PDF]

J Exp Bot
Sadras V, Welsh M, Sznajder B, Hayes J, Reynolds M, Taylor J.   +5 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Grain protein and yield stability study in rainfed durum wheat RILs. [PDF]

Sci Rep
Ghanbari S, Cheghamirza K, Zarei L, Naseri R, Desiderio F, Virzi N, Sciacca F, Palumbo M, Mazzucotelli E.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Dissecting the genetic basis of yield stability in faba bean by multi-environment analysis. [PDF]

Genome Biol
Bornhofen E, Mouritzen TW, Alves S, Robertson-Shersby-Harvie TR, Skovbjerg CK, Windhorst A, Zhang H, Jayakody TB, Zhang J, Nadzieja M, Shim H, Magnin-Robert JB, Aubert G, Floriot M, Guiziou C, Sass O, Welna G, Solís I, Nielsen LK, Gutiérrez N, Jayakodi M, Stoddard FL, O'Sullivan DM, Torres AM, Link W, Tayeh N, Janss L, Andersen SU.   +27 more
europepmc   +1 more source

Changes in Producers’ Perceptions of Within-field Yield Variability Following Adoption of Cotton Yield Monitors [PDF]

Precision Farming, Risk, Yield Monitor, Yield Variability, Yield Perceptions, Spatial Yield Distributions, Within Field Variability, Farm Management, Production Economics, Risk and Uncertainty, Q12, Q16,
Roberts, Roland K., English, Burton C., Larson, James A., Marra, Michele C., Rejesus, Roderick M., Paxton, Kenneth W.   +5 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Plasticity of source-sink dynamics contributes to wheat yield stability. [PDF]

Nat Commun
Wang TC, Moritz A, Mabrouk M, Villar Alegría E, Arinalp B, Ganji E, Förter L, Wittkop B, Herzog E, Snowdon RJ, Stahl A, Chen TW.   +11 more
europepmc   +1 more source