Results 71 to 80 of about 6,926,535 (359)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Theoretical strength and homogeneous sliding in metallic glass: exactly solvable model
Journal of the Mechanical Behavior of Materials, 2013 At low temperature, T→0, the yield stress of a perfect crystal is equal to its so-called theoretical strength. The yield stress of nonperfect crystals is controlled by the stress threshold of dislocation mobility.
Lazarev Nikolai, Bakai Alexander
doaj +1 more source
Materials & Design (1980-2015), 2019 The yield strength and work hardening properties of an Al-Cu-Li alloy AA2050 after artificial ageing have been experimentally investigated and modelled in this study.
Yong Li, Zhusheng Shi, Jianguo Lin
semanticscholar +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Metals, 2018 The effects of warm rolling reduction ratio ranging from 20% to 55% on microstructure evolution, the tensile deformation mechanism, and the associated mechanical properties of an Fe-30Mn-4Si-2Al TRIP/TWIP steel were studied.
Yanchun Dong +10 more
doaj +1 more source
Study on Pressure Release Performance of a New Type of Anchor Cable Pressure Release Device
Meikuang Anquan, 2020 This paper presents a new type of anchor cable pressure release device, which is composed of the pressure release pipe and the pressure plug. The device is installed between the support plate and the lock, no reaming is required, and it has low cost ...
WU Yuyi
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Experimental study of the fluidity of nanostructured magnetic fluid in a strong magnetic field
Физико-химические аспекты изучения кластеров, наноструктур и наноматериаловBased on magnetic fluids, new effective technical devices have been implemented, such as magnetic fluid bearings, seals, and dampers. The magnetic-viscous effect inherent to magnetic fluids can not only improve the properties of magnetic fluid units, but
A.N. Bolotov, O.O. Novikova
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source