Results 71 to 80 of about 427,988 (311)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Theoretical strength and homogeneous sliding in metallic glass: exactly solvable model

Journal of the Mechanical Behavior of Materials, 2013
At low temperature, T→0, the yield stress of a perfect crystal is equal to its so-called theoretical strength. The yield stress of nonperfect crystals is controlled by the stress threshold of dislocation mobility.
Lazarev Nikolai, Bakai Alexander
doaj   +1 more source

Towards stochastic simulation of crop yield: a case study of fruit set in sweet pepper

, 2010
Crop growth simulation models are widely used in research and education, and their use in commercial practice is increasing. Usually these models are deterministic: one set of input values always gives the same output of the model.
Wubs, A.M.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Influence of Warm Rolling Reduction on Microstructure Evolution, Tensile Deformation Mechanism and Mechanical Properties of an Fe-30Mn-4Si-2Al TRIP/TWIP Steel

Metals, 2018
The effects of warm rolling reduction ratio ranging from 20% to 55% on microstructure evolution, the tensile deformation mechanism, and the associated mechanical properties of an Fe-30Mn-4Si-2Al TRIP/TWIP steel were studied.
Yanchun Dong, Zhilin Sun, Hao Xia, Jianhang Feng, Jiejie Du, Wei Fang, Baoxi Liu, Gongkai Wang, Long Li, Xin Zhang, Fuxing Yin   +10 more
doaj   +1 more source

Study on Pressure Release Performance of a New Type of Anchor Cable Pressure Release Device

Meikuang Anquan, 2020
This paper presents a new type of anchor cable pressure release device, which is composed of the pressure release pipe and the pressure plug. The device is installed between the support plate and the lock, no reaming is required, and it has low cost ...
WU Yuyi
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Experimental study of the fluidity of nanostructured magnetic fluid in a strong magnetic field

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
Based on magnetic fluids, new effective technical devices have been implemented, such as magnetic fluid bearings, seals, and dampers. The magnetic-viscous effect inherent to magnetic fluids can not only improve the properties of magnetic fluid units, but
A.N. Bolotov, O.O. Novikova
doaj   +1 more source

Strength modelling of Al-Cu-Mg Type alloys

, 2006
Age hardening of Al-Cu-Mg type alloys occurs in two stages separated by a constant hardness plateau when the alloys are aged at 110°C to 240?C after solution treatment and quenching.
Yan, Jialin
core