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Critical Reviews− in Oncogenesis, 2011
The transcription factor Yin Yang (YY) 1 controls many divergent cellular processes, including cell proliferation and apoptosis. These are key to cancer development, as a consequence of which its expression has been studied in an increasingly wide range of human cancers, including lymphoma, breast, prostate, colon, ovarian, cervical, and brain cancers,
Nicholson, Sarah +3 more
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The transcription factor Yin Yang (YY) 1 controls many divergent cellular processes, including cell proliferation and apoptosis. These are key to cancer development, as a consequence of which its expression has been studied in an increasingly wide range of human cancers, including lymphoma, breast, prostate, colon, ovarian, cervical, and brain cancers,
Nicholson, Sarah +3 more
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Yin Yang 1: Function, Mechanisms, and Glia
Neurochemical ResearchAbstract Yin Yang 1 is a ubiquitously expressed transcription factor that has been extensively studied given its particular dual transcriptional regulation. Yin Yang 1 is involved in various cellular processes like cell cycle progression, cell differentiation, DNA repair, cell survival and apoptosis among others. Its malfunction or alteration
Laura Isabel Mendez Aldana +2 more
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2007
The transcription factor Yin Yang 1 (YY1) (also known as NF-E1, δ, CP-1 and UCRBP) is a GLI-Kruppel zinc finger protein. 1–4YY1 is highly conserved from Xenopus to mammalian YY1 and has been demonstrated to play an essential role in mouse embryonic development and other physiological and pathological conditions.5, 6 As one of the first mammalian ...
Huifei Liu, Yang Shi
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The transcription factor Yin Yang 1 (YY1) (also known as NF-E1, δ, CP-1 and UCRBP) is a GLI-Kruppel zinc finger protein. 1–4YY1 is highly conserved from Xenopus to mammalian YY1 and has been demonstrated to play an essential role in mouse embryonic development and other physiological and pathological conditions.5, 6 As one of the first mammalian ...
Huifei Liu, Yang Shi
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LOX-1/LOXIN: The Yin/Yang of Atheroscleorosis
Cardiovascular Drugs and Therapy, 2011Atherosclerosis is the first cause of death in industrialized countries. Together with traditional risk factors (male gender, hypercholesterolemia, hypertension, diabetes, smoking and age), non-traditional risk factors have also been described as predisposing to this disease. Among these, oxidized low density lipoproteins (OxLDL) have been described in
Ruggiero, Mango +3 more
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Endothelin-1: The Yin and Yang on Vascular Function
Current Medicinal Chemistry, 2006Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which acts as the natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to vascular tone and regulates cell proliferation through activation of ETA and ETB receptors. Physical factors such as shear stress, or stimuli including thrombin, epinephrine, angiotensin
Marasciulo FL +2 more
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Yin-Yang 1, a New Player in Early Heart Development [PDF]
Circulation Research, 2013 In this issue of Circulation Research , Gregoire et al1 report their discovery that Yin-Yang 1 (YY1) is a critical factor for the transition from cardiac progenitor to differentiated cardiomyocyte. The authors made clever use of currently available transcription factor (TF)-binding databases to perform a bioinformatic-based screen for factors ...
John Leach +2 more
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Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4
Archives of Pharmacal Research, 2015Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is regulated by inducible or constitutive factors. Yin-Yang (YY)-1 is one of constitutive transcription factors binding to the IL-4 promoter.
Sung Ho, Lee +6 more
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Yin Yang 1 Expression in the Adult Rodent Brain
Neurochemical Research, 2008Yin Yang 1 (YY1) is a ubiquitous transcription factor belonging to Polycomb group proteins. Its expression patterns in the adult brain have not been before clearly elucidated. Using immunohistochemical stainings, we show a distribution of YY1 protein throughout the adult rodent brain.
Marcin, Rylski +5 more
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Yin Yang 2: The Great Unknown within the Yin Yang 1 Regulatory Network
Critical Reviews− in Oncogenesis, 2011The fundamental biological relevance of the transcription factor Yin Yang 1 (YY1) has been studied and described intensively in hundreds of publications. To date, however, only limited data of its structural and functional homologue YY2 are available. Especially, the impact of Yin Yang 2 (YY2) in the regulatory network of YY1 is almost unexplored. This
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