Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer Therapy [PDF]
BiomoleculesTumor drug resistance, a major cause of treatment failure, involves complex multi-gene networks, remodeling of signaling pathways, and interactions with the tumor microenvironment.
Zhiyan Li +4 more
doaj +7 more sources
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1 [PDF]
Frontiers in Cell and Developmental Biology, 2020 First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously expressed throughout mammalian cells. It regulates both transcriptional activation and repression, in a seemingly context-dependent manner.
Thijs C. J. Verheul +3 more
doaj +8 more sources
Hepatic expression of Yin Yang 1 (YY1) is associated with the non-alcoholic fatty liver disease (NAFLD) progression in patients undergoing bariatric surgery [PDF]
BMC Gastroenterology, 2018 Background This study is to investigate the association between the hepatic expression of Yin Yang 1 (YY1) and the progression of non-alcoholic fatty liver disease (NAFLD) in patients undergoing bariatric surgery.
Xianwen Yuan +10 more
doaj +4 more sources
Induction of Yin Yang 1 (YY1) Overexpression in Mature Adipocytes Promotes Dysfunctional Adipose Tissue and Systemic Insulin Resistance in Mice [PDF]
Metabolism: Clinical and ExperimentalThe ubiquitous transcription factor Ying Yang 1 (YY1) plays a fundamental role in multiple biological processes and is believed to regulate up to 10 % of all human genes. In thermogenic brown adipose tissue, YY1 has been linked to controlling mitochondrial gene expression and regulating cellular oxidative respiration, protecting against diet-induced ...
Pedersen L +10 more
exaly +5 more sources
CRTAC1 (Cartilage Acidic Protein 1) Inhibits Cell Proliferation, Migration, Invasion and Epithelial-Mesenchymal Transition (EMT) Process in Bladder Cancer by Downregulating Yin Yang 1 (YY1) to Inactivate the TGF-β Pathway [PDF]
Bioengineered, 2021 Cartilage acidic protein 1 (CRTAC1) is predicted to be aberrantly expressed in bladder cancer based on bioinformatics analysis. However, its functions and molecular mechanism in bladder cancer remain elusive. This study aimed to explore the role of CRTAC1 in bladder cancer.
Hailong Hu, Xiaoxing Liao
exaly +5 more sources
Astrocytic Yin Yang 1 Is Critical for Murine Brain Development and Protection Against Apoptosis, Oxidative Stress, and Inflammation [PDF]
Glia, 2023 Eunsook Y Lee +2 more
exaly +2 more sources
Yin Yang 1 Promotes Antiprogrammed Cell Death‐1 Resistance in Hepatocellular Carcinoma through Polypeptide N‐Acetylgalactosaminyltransferase 16‐Mediated Glycosylation of Programmed Death Ligand‐1 [PDF]
MedCommImmune checkpoint inhibitors (ICIs) are widely used for treating hepatocellular carcinoma (HCC), yet their efficacy remains limited, with suboptimal response rates.
Shu‐sheng Lin +11 more
doaj +2 more sources
Unraveling the RKIP–YY1 axis: immune crosstalk in the pathogenesis of metabolic disorders [PDF]
Frontiers in ImmunologyMetabolic diseases, including obesity, type 2 diabetes, and cardiovascular disorders, are increasingly recognized as chronic inflammatory conditions driven by dysregulated immune-metabolic interactions.
Fawaz Alzaid +10 more
doaj +2 more sources
Cell Death and Disease, 2022 Methyltransferase-like protein 3 (METTL3) plays critical roles in acute myeloid leukemia (AML) progression, however, the mechanism of abnormal overexpression of METTL3 in AML remain elusive.
Meng Li +9 more
doaj +1 more source
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment
Frontiers in Oncology, 2023 Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression.
MengNa Li +33 more
doaj +1 more source