Results 11 to 20 of about 111,329,672 (189)
A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes
Gene, 2006 The RNA polymerase (pol) II and III human small nuclear RNA (snRNA) genes have very similar promoters and recruit a number of common factors. In particular, both types of promoters utilize the small nuclear RNA activating protein complex (SNAP(c)) and the TATA box binding protein (TBP) for basal transcription, and are activated by Oct-1.
Emran, F. +5 more
openaire +4 more sources
Yin Yang 1 Dynamically Regulates Antiviral Innate Immune Responses During Viral Infection
Cellular Physiology and Biochemistry, 2017 Background/Aims: Type I interferon (IFN-1) production and IFN-1 signaling play critical roles in the host antiviral innate immune responses. Although transcription factor Yin Yang 1 (YY1) has been reported to have a dual activator/repressor role during ...
Jie Zan +7 more
doaj +3 more sources
Genomics Data, 2016 Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery and functional annotation of Linc-YY1, a novel lincRNA originating from the promoter of the transcription factor (TF) Yin Yang 1 (YY1).
Kun Sun +4 more
doaj +2 more sources
Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1 [PDF]
Cell Reports, 2013 Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized.
Sharon Schlesinger +4 more
doaj +2 more sources
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner [PDF]
Nature Communications, 2019 The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of ...
Luis Zurkirchen +11 more
doaj +2 more sources
The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiation [PDF]
Blood, 2003 AbstractThe genetic defects underlying the pathogenesis of acute myeloid leukemia (AML) are still largely unknown. Retroviral insertion mutagenesis in mice has become a powerful tool to identify candidate genes involved in the development of leukemia and lymphoma.
Erkeland, Stefan +6 more
core +6 more sources
Cell Death and DiseaseYin Yang 1 (YY1) is a key transcription factor that has been implicated in the development of several malignancies. The stability of YY1 is regulated by the ubiquitin-proteasome system. The role of deubiquitinases (DUBs) and their impact on YY1 remain to
Liang Wu +8 more
doaj +2 more sources
The role of Yin and Yang 1 (YY1) transcription factor in acute myeloid leukemia (AML) [PDF]
, 2020 “The role of Yin and Yang 1 (YY1) transcription factor in Acute Myeloid Leukemia (AML)” Introduction: Acute Myeloid Leukemia is an heterogeneous disease with different molecular signatures, therapeutic responses, and survival rates. Recent studies suggest that the transcription factor YY1 is overexpressed in AML patients and it may have a role in the ...
SCALEA, STEFANIA
openaire +2 more sources
Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6. [PDF]
PLoS ONE, 2018 The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown.
Wanxue Wang +8 more
doaj +2 more sources
A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells
Journal of Translational Medicine, 2017 Background Autophagy is a highly regulated biological process that mediates the degradation of intracellular components. It is required for tumor cell metabolism and homeostasis.
Chuang Yang +8 more
doaj +2 more sources