The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis
Cell Death and DiseaseColorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression.
Zhi-Ying Shao +8 more
doaj +2 more sources
Yin Yang 1 (YY1): Regulation of Survivin and Its Role In Invasion and Metastasis. [PDF]
Crit Rev Oncog, 2017 Despite significant clinical and basic science advancements, cancer remains a devastating disease that affects people of all ages, races, and backgrounds. The pathogenesis of cancer has recently been described to result from eight biological capabilities or hallmarks and two enabling characteristics.
Galloway NR, Ball KF, Stiff T, Wall NR.
europepmc +4 more sources
PLoS ONEThe protein Yin-Yang 1 (YY1) is a ubiquitous multifunctional transcription factor. Interestingly, there are several cellular functions controlled by YY1 that could play a role in Leishmania pathogenesis.
Harsimran Kaur Brar +8 more
doaj +2 more sources
Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1). [PDF]
J Biol Chem, 2015 Astrocytic glutamate transporter excitatory amino acid transporter (EAAT) 1, also known as glutamate aspartate transporter (GLAST) in rodents, is one of two glial glutamate transporters that are responsible for removing excess glutamate from synaptic clefts to prevent excitotoxic neuronal death.
Karki P +5 more
europepmc +4 more sources
LncRNA SOX2-OTinhibitionprotects against myocardialischemia/reperfusion-inducedinjury via themicroRNA-186-5p (miR-186-5p)/Yin Yang 1 (YY1)pathway. [PDF]
Bioengineered, 2022 Long noncoding RNAs (lncRNAs) exert essential effects in regulating myocardial ischemia/reperfusion (MI/R)-induced injury. This work intended to explore the functions of lncRNA SOX2-OT and its regulatory mechanism within MI/R-induced injury. In this study, gene expression was determined by RT-qPCR.
Yang P +8 more
europepmc +3 more sources
Early-Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice. [PDF]
Adv Sci (Weinh)Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Chen K, He B, Liu K, Ma Z, Xu B.
europepmc +2 more sources
DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs. [PDF]
Adv Sci (Weinh)p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Lv Y +15 more
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Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate. [PDF]
Chem BiodiversCF‐Paeonol, a molecular hybrid of clofibric acid and paeonol, retains lipid‐lowering activity while producing markedly less hepatic injury than clofibrate (CF) in mice. Its benefits are accompanied by improved bile acid homeostasis, reduced oxidative stress and inflammation, decreased YY1 expression, and increased FXR expression, supporting molecular ...
Tu H +10 more
europepmc +2 more sources
Regulation of Krüppel-Like Factor 4 (KLF4) expression through the transcription factor Yin-Yang 1 (YY1) in non-Hodgkin B-cell lymphoma. [PDF]
Oncotarget, 2019 Krüppel-Like Factor 4 (KLF4) is a member of the KLF transcription factor family, and evidence suggests that KLF4 is either an oncogene or a tumor suppressor. The regulatory mechanism underlying KLF4 expression in cancer, and specifically in lymphoma, is still not understood.
Morales-Martinez M +10 more
europepmc +5 more sources
Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes. [PDF]
GliaCerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Zarei-Kheirabadi M +9 more
europepmc +2 more sources