Results 41 to 50 of about 111,329,672 (189)

Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD

Nature Communications, 2023
The GGGGCC hexanucleotide repeat expansion mutation in the chromosome 9 open reading frame 72 (C9orf72) gene is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD).
Zhefan Stephen Chen, Mingxi Ou, Stephanie Taylor, Ruxandra Dafinca, Shaohong Isaac Peng, Kevin Talbot, Ho Yin Edwin Chan   +6 more
doaj   +1 more source

The Yin and Yang of YY1 in tumor growth and suppression [PDF]

International Journal of Cancer, 2018
Yin Yang‐1 (YY1) is a zinc finger protein and member of the GLI‐Kruppel family that can activate or inactivate gene expression depending on interacting partners, promoter context and chromatin structure, and may be involved in the transcriptional control of ∼10% of the total mammalian gene set.
openaire   +2 more sources

The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle. [PDF]

PLoS ONE, 2012
Yin Yang 1 (YY1) is a ubiquitously expressed and highly conserved multifunctional transcription factor that is involved in a variety of cellular processes. Many YY1-regulated genes have crucial roles in cell proliferation, differentiation, apoptosis, and
Ari Kassardjian, Raed Rizkallah, Sarah Riman, Samuel H Renfro, Karen E Alexander, Myra M Hurt   +5 more
doaj   +1 more source

The Yin Yang-1 (YY1) protein undergoes a DNA-replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase [PDF]

Journal of Cell Science, 2004
The essential Yin Yang-1 gene (YY1) encodes a ubiquitous, conserved, multifunctional zinc-finger transcription factor in animals. The YY1 protein regulates initiation, activation, or repression of transcription from a variety of genes required for cell growth, development, differentiation, or tumor suppression, as well as from genes in some ...
Linda, Palko, Hank W, Bass, Maroun J, Beyrouthy, Myra M, Hurt   +3 more
openaire   +2 more sources

Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. [PDF]

, 2015
Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the ...
Choi, Murim, Stalberg, Peter, Mane, Shrikant, Kunstman, John, Björklund, Peyman, Åkerström, Göran,, Korah, Reju, Overton, John D., Lifton, Richard P., Westin, Gunnar,, Malchoff, Carl D., Hellman, Per, Fonseca, Annabelle L., Cromer, M. Kyle, Kenney, Barton, Nelson-Williams, Carol, Kunstman, John W., Björklund, Peyman,, Lifton, Richard, Hellman, Per,, Westin, Gunnar, Akerström, Göran, Fonseca, Annabelle, Overton, John, Carling, Tobias, Stålberg, Peter,, Malchoff, Carl, Korah, Reju M., Cromer, M   +28 more
core   +1 more source

YY1-binding sites provide central switch functions in the PARP-1 gene expression network.

PLoS ONE, 2012
Evidence is presented for the involvement of the interplay between transcription factor Yin Yang 1 (YY1) and poly(ADP-ribose) polymerase-1 (PARP-1) in the regulation of mouse PARP-1 gene (muPARP-1) promoter activity.
Martina Doetsch, Angela Gluch, Goran Poznanović, Juergen Bode, Melita Vidaković   +4 more
doaj   +1 more source

Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis

Molecular Brain, 2020
The highly conserved and ubiquitously expressed transcription factor Yin Yang 1 (Yy1), was named after its dual functions of both activating and repressing gene transcription.
Xiaonan Dong, Kin Ming Kwan
doaj   +1 more source

Statement of Retraction: LncRNA SOX2-OTinhibitionprotects against myocardialischemia/reperfusion-inducedinjury via themicroRNA-186-5p (miR-186-5p)/Yin Yang 1 (YY1)pathway. [PDF]

Bioengineered
europepmc   +2 more sources

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation [PDF]

, 2019
Increasing evidence suggests that cancer cells highjack developmental programs for disease initiation and progression. Melanoma arises from melanocytes that originate during development from neural crest stem cells (NCSCs).
Aerts, Stein, Varum, Sandra, Bossart, Raphaël, Atak, Zeynep Kalender, Tuncer, Eylül, Zingg, Daniel, Sommer, Lukas, John, Nessy, Levesque, Mitchell P, Häusel, Jessica, Zurkirchen, Luis, Tuncer, Eyluel, Veen, Dominiek, Dummer, Reinhard, Haeusel, Jessica, Baggiolini, Arianna, Marzorati, Elisa, Basler, Konrad, Zamboni, Nicola, Wouters, Jasper, Balz, Marcel, Cantù, Claudio, Levesque, Mitchell P., Basler, Konrad; https://orcid.org/, Atak, Zeynep Kalender,, Dummer R, Varum S, John N, Dummer, Reinhard,, Häusel, Jessica,, Wouters J, Zamboni N, Levesque MP, Bossart R, Cantù C, Varum, Sandra,, Atak ZK, Tuncer, Eylül,, Aerts, Stein,, Veen D, Veen, Dominiek,, Sommer, Lukas,, Marzorati, Elisa,, Bossart, Raphaël,, Sommer L, John, Nessy,, Balz M, Zurkirchen L, Baggiolini, Arianna,, Basler K, Zamboni, Nicola,, Baggiolini A, Häusel J, Basler, Konrad,, Wouters, Jasper,, Tuncer E, Cantù, Claudio,, Zingg D, Zurkirchen, Luis,, Balz, Marcel,, Zingg, Daniel,, Aerts S, Marzorati E, Levesque, Mitchell P,   +63 more
core   +1 more source

Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. [PDF]

, 2021
Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatment.
Huang, Jiaoti, Wang, Gang Greg, Zheng, Deyou, Edmondson, Ricky D, Byrum, Stephanie D, Parker, Joel S, Xu, Chenxi, Gong, Weida, Earp, H Shelton, Tsai, Yi-Hsuan, Cai, Ling, Storey, Aaron J, Xu, Lingfan, Xu, Yuemei, Mackintosh, Samuel G, Tackett, Alan J, Galbo, Phillip M, Whang, Young E, Weida Gong, Chenxi Xu, Ricky D Edmondson, Jiaoti Huang, Stephanie D Byrum, H Shelton Earp, Ling Cai, Deyou Zheng, Yi-Hsuan Tsai, Samuel G Mackintosh, Alan J Tackett, Aaron J Storey, Phillip M Galbo, Lingfan Xu, Joel S Parker, Yuemei Xu, Young E Whang, Gang Greg Wang   +35 more
core   +2 more sources