Results 61 to 70 of about 111,329,672 (189)

Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines. [PDF]

PLoS ONE, 2012
Prostate cancer is influenced by epigenetic modification of genes involved in cancer development and progression. Increased expression of Prostate Stem Cell Antigen (PSCA) is correlated with development of malignant human prostate cancer, while studies ...
Shuai Tang, Meenu Mishra, Donna P Frazier, Miranda L Moore, Kazushi Inoue, Rajendar Deora, Guangchao Sui, Purnima Dubey   +7 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1

, 2015
Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis
Lu, Leina, Zhang, Suyang, Zhao, Yu, Tang, Ling Yin, Zhou, Liang, Wang, Xuecong, Chen, Fengyuan, Wang, Huating, Sun, Kun, Jauch, Ralf, Bao, Xichen, Li, Yuying, Wang, Lijun, Wang, Chi Chiu, Chen, Xiaona, Zhu, Xihua, Esteban, Miguel A., Sun, Hao   +17 more
core   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Yin Yang 1 and Raf-1 Kinase Inhibitory Protein Status in Hepatocellular Carcinoma: Future Perspectives

, 2010
We focus on to the role of the transcription factors NF-κB and Yin Yang 1 (YY1) and of Raf-1 kinase inhibitory protein (RKIP) in hepatocellular carcinoma (HCC). YY1, whose expression is enhanced by NF-κB, favors tumorigenesis. RKIP inhibits the oncogenic
LABBOZZETTA, Manuela, FLORENA, Ada Maria, PORCASI, Rossana, GIANNITRAPANI, Lydia, Cervello, M, D'ALESSANDRO, Natale, MONTALTO, Giuseppe, NOTARBARTOLO DI VILLAROSA, Monica, POMA, Paola, INGUGLIA, Luigi, Luigi Inguglia, Giuseppe Montalto, Manuela Labbozzetta, Rossana Porcasi, Melchiorre Cervello, Ada Maria Florena, Monica Notarbartolo, Natale D'Alessandro, Lydia Giannitrapani, Paola Poma   +19 more
core   +1 more source

Dissecting the Radioresponse Heterogeneity of Lung Adenocarcinoma Cells From the Perspective of Transcriptional and Regulatory Landscape

MedComm, Volume 7, Issue 11, November 2026.
Radiation‐associated transcriptional and regulatory cell states drive heterogeneous radioresponses in isogenic lung adenocarcinoma cells. ABSTRACT Radioresistance severely compromises radiotherapy efficacy for lung adenocarcinoma (LUAD), yet the intrinsic heterogeneity of cellular radioresponses among isogenic tumor cells remains poorly characterized ...
Huan Tao, Yaru Li, Leixin Ge, Lu Chen, Yang Zheng, Feiyue Ma, Changhui Ge, Hanjiang Fu, Yu Sun, Longteng Wang, Junting Wang, Xuemei Bai, Hao Li, Xiaochen Bo, Hebing Chen, Xiaofei Zheng   +15 more
wiley   +1 more source

YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

Stem Cell Reports, 2018
Summary: Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells.
Jia Wang, Xingui Wu, Chao Wei, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang, Junjun Ding   +21 more
doaj   +1 more source

YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation

Scientific Reports, 2020
Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro.
Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li   +18 more
doaj   +1 more source

Host cells reprogram lipid droplet synthesis through YY1 to resist PRRSV infection

mBio
Metabolism in host cells can be modulated after viral infection, favoring viral survival or clearance. Here, we report that lipid droplet (LD) synthesis in host cells can be modulated by yin yang 1 (YY1) after porcine reproductive and respiratory ...
Zifang Zheng, Xue Ling, Yang Li, Shuang Qiao, Shuangquan Zhang, Jie Wu, Zhiqian Ma, Mingyu Li, Xuyang Guo, Zhiwei Li, Yingtong Feng, Xiao Liu, Ian G. Goodfellow, Haixue Zheng, Shuqi Xiao   +14 more
doaj   +1 more source

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity

Molecular Therapy: Nucleic Acids, 2020
Transcription factor Yin Yang 1 (YY1) is upregulated in multiple tumors and plays essential roles in tumor proliferation and metastasis. However, the function of YY1 in breast cancer stemness remains unclear.
Qianqian Guo, Ting Wang, Yue Yang, Lanlan Gao, Qiong Zhao, Wenzhou Zhang, Tao Xi, Lufeng Zheng   +7 more
doaj   +1 more source