Results 51 to 60 of about 111,329,672 (189)

Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer

Indian Journal of Pathology and Microbiology, 2021
Background: Yin Yang 1 (YY1), the multifunctional transcription factor, has recently been assigned biological properties related to human malignancies. YY1 can facilitate both tumor suppression and tumor growth.
Hyunsung Kim, Seongsik Bang, Seungyun Jee, Seongeon Park, Yeseul Kim, Hosub Park, Kiseok Jang, Seung Sam Paik   +7 more
doaj   +1 more source

Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1 [PDF]

, 2020
Abraxas brother protein 1 (ABRO1) is a subunit of the deubiquitinating enzyme BRCC36-containing isopeptidase complex and plays important roles in cellular responses to stress by interacting with its binding partners, such as ubiquitin-specific peptidase ...
Li, Changyan, Ge, Changhui, Hong, Jian, Yin, Ronghua, Yu, Miao, Yang, Xiaoming, Wang, Yuan, Song, Pan, Zhan, Yiqun, Yao, Xuelian, Pan Song, Miao Yu, Xuelian Yao, Changyan Li, Yuan Wang, Changhui Ge, Jian Hong, Xiaoming Yang, Ronghua Yin, Yiqun Zhan   +19 more
core   +1 more source

Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence

Cell Reports, 2018
Summary: Yin yang 1 (YY1) is a ubiquitous transcription factor and mammalian polycomb group protein (PcG) with important functions to regulate embryonic development, lineage differentiation, and cell proliferation.
Zhanping Lu, Courtney C. Hong, Guangyao Kong, Anna L.F.V. Assumpção, Irene M. Ong, Emery H. Bresnick, Jing Zhang, Xuan Pan   +7 more
doaj   +1 more source

Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non‐canonical WNT pathway (FYN/STAT3)

Clinical and Translational Medicine, 2023
Background A growing number of studies have shown that Yin Yang 1 (YY1) promotes the development of multiple tumours. The purpose of the current study was to determine the mechanism by which YY1 mediates neuroendocrine differentiation of prostate cancer (
Rui‐ji Liu, Zhi‐Peng Xu, Xiang Huang, Bin Xu, Ming Chen   +4 more
doaj   +1 more source

YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA

Frontiers in Oncology, 2019
Hepatocellular carcinoma (HCC) is a typical hypervascular solid tumor that requires neoangiogenesis for growth. The vascular endothelial growth factor (VEGF) is the most potent proangiogenic factor in neovascularization.
Wendong Yang, Zhongwei Li, Zhongwei Li, Rong Qin, Rong Qin, Xiaorui Wang, Huihui An, Huihui An, Yule Wang, Yule Wang, Yan Zhu, Yan Zhu, Yantao Liu, Yantao Liu, Shijiao Cai, Shuang Chen, Tao Sun, Tao Sun, Jing Meng, Jing Meng, Cheng Yang, Cheng Yang   +21 more
doaj   +1 more source

Increased Expression of miR-326 Mediates Chemosensitivity in Pediatric Acute Lymphoblastic Leukemia Through <i>ABCA2</i> and <i>YY1</i> Downregulation: An Observational and Experimental Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Multidrug resistance (MDR) is a major determinant of relapse‐associated mortality in pediatric acute lymphoblastic leukemia (pALL). Although miR‐326 downregulation has been associated with poor prognosis, its role in chemoresistance remains undefined. This study investigated the mechanistic contribution of miR‐326 to MDR in
Aberuyi N, Rahgozar S, Katebi M.
europepmc   +2 more sources

YY1 Promotes Telomerase Activity and Laryngeal Squamous Cell Carcinoma Progression Through Impairment of GAS5-Mediated p53 Stability

Frontiers in Oncology, 2021
Yin Yang 1 (YY1) is a key transcription factor that exerts functional roles in the cell biological process of various cancers. The current study aimed to elucidate the role and mechanism of YY1 in laryngeal squamous cell carcinoma (LSCC).
Xudong Wei, Xudong Wei, Xudong Wei, Fenglei Liu, Fenglei Liu, Xuelian Jiang, Xuelian Jiang, Xiaoyan Xu, Xiaoyan Xu, Tianhao Zhou, Tianhao Zhou, Chengfang Kang, Chengfang Kang   +12 more
doaj   +1 more source

YY1 involvement in embryonic development and cancer

, 2020
Despite numerous advances in the field of cancer cell biology, the origin of cancer cells and the systemic disruptions in the cancer process of normal cells have not yet been fully identified.
Acikgoz E., Sati L., Leyla Sati, Gulperi Oktem, Eda Acikgoz, Oktem G., Acikgoz, E., Sati, L., Oktem, G.   +8 more
core   +1 more source

YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis

JCI Insight, 2021
Th17 cells are involved in rheumatoid arthritis (RA) pathogenesis. Our previous studies have revealed that transcription factor Yin Yang 1 (YY1) plays an important role in the pathogenic mechanisms of RA.
Jinpiao Lin, Jifeng Tang, Junyu Lin, Yujue He, Ziqing Yu, Renquan Jiang, Bin Yang, Qishui Ou   +7 more
doaj   +1 more source

Multifunctional YY1 in Liver Diseases

, 2017
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the cellular context.
Yuzhang Wu, Shuang Yang, Mengjie Zhang, Weiwu Gao, Xia Yang, Zhiqiang Tian, Jian Zhou, Yi Zhang, Di Yang, Bing Ni   +9 more
core   +1 more source