Results 51 to 60 of about 111,326,060 (152)
eLife, 2019 Genes can encode multiple isoforms, broadening their functions and providing a molecular substrate to evolve phenotypic diversity. Evolution of isoform function is a potential route to adapt to new environments.
Wen Xu +7 more
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Mechanisms of Yin Yang 1 in Oncogenesis: The Importance of Indirect Effects [PDF]
Critical Reviews− in Oncogenesis, 2011 Yin Yang 1 (YY1) is a ubiquitously expressed transcription factor that performs numerous functions including transcriptional regulation, cell growth control, apoptosis, large-scale chromosomal dynamics, and X-chromosome inactivation. YY1 clearly is able to control cell functions, including proliferation, by acting as a transcription factor either to ...
Michael, Atchison +3 more
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Molecular Therapy: Nucleic AcidsAnorectal malformations (ARMs) are congenital diseases that lead to postoperative fecal incontinence, constipation, and soiling, despite improvements in surgery; however, their pathological mechanisms remain unclear.
Yue Li +7 more
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MicroRNA-122 Inhibits Lipid Droplet Formation and Hepatic Triglyceride Accumulation via Yin Yang 1
Cellular Physiology and Biochemistry, 2017 Background/Aims: An increase in intracellular lipid droplet formation and hepatic triglyceride (TG) content usually results in nonalcoholic fatty liver disease.
Guo-yi Wu +6 more
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Molecular Brain, 2020 The highly conserved and ubiquitously expressed transcription factor Yin Yang 1 (Yy1), was named after its dual functions of both activating and repressing gene transcription.
Xiaonan Dong, Kin Ming Kwan
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The concept of Yin and Yang in Bright Sheng’s “My Other Song”
, 2022 This paper explores the ancient Chinese concepts involved in Bright Sheng's solo piano work “My Other Song,” as well as the compositional developments between “My Other Song” and “My Song” composed 17 years apart, drawing on the composer's answer, “I ...
Qian, Deng, Loo, Fung Chiat
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Advanced ScienceActivated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases.
Jiaxing Huang +14 more
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Transcription Regulator Yin-Yang 1: From Silence to Cancer [PDF]
Critical Reviews− in Oncogenesis, 2011 Yin Yang (YY) 1 represents the epitome of what is considered to be a "Swiss army knife" transcription factor and regulator. YY1 is a ubiquitous and multifunctional zinc-finger transcription factor member of the Polycomb group protein family, a group of homeobox gene receptors that can act as activators or repressors of transcriptional activity ...
Weidong, Zhu +2 more
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MTY001 probiotic improves muscle mass and function in a dexamethasone-induced atrophy mouse model
Journal of Functional FoodsBackground: Muscle atrophy is a critical health concern requiring effective therapeutic strategies. Probiotics show potential via the gut-muscle axis. This study screened for probiotic strains with anti–muscle atrophy properties.
Meehee Park +5 more
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Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation [PDF]
Journal of Molecular Cell Biology, 2016 Yin Yang 1 (YY1) regulates both gene expression and protein modifications, and has shown a proliferative role in cancers. In this study, we demonstrate that YY1 promotes AKT phosphorylation at S473, a marker of AKT activation. YY1 expression positively correlated with AKT(S473) phosphorylation in a tissue microarray and cultured cells of breast cancer,
Qiang, Zhang +8 more
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