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Ten principles of residential child care
The history of residential care for children and young people is quite extensive and features positive stories of resilience and adult-child relationships as well as negative stories of institutional abuse and the abdication of adult responsibility ...
Kiaras Gharabaghi
doaj +1 more source
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu +7 more
wiley +1 more source
All things being equal? Equality and diversity in careers education,information, advice and guidance [PDF]
In its education chapter, the Commission’s first Triennial Review of evidence on inequality, How Fair is Britain? Equality, Human Rights and Good Relations in 2010, found that educational attainment has been transformed in recent years.
Bentley, Kieran +4 more
core +1 more source
Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin +19 more
wiley +1 more source
Creative, participatory projects with young people: Reflections over five years
Participatory research is collaborative and democratic, and may be particularly engaging for vulnerable or so-called hard-to-reach groups. In this paper, we describe three creative participatory projects carried out over five years with young people and
doaj +2 more sources
Social Situation of Young People in Europe [PDF]
[Excerpt] European policy on the situation of young people is framed by the EU Youth Strategy 2010–2018, which has two overall objectives: to provide more and equal opportunities for young people in education and in the labour market; and to encourage ...
Eurofound
core +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Extending boundaries: young people as action researchers [PDF]
Action research is generally undertaken by adults as a process of systematic action planning and enquiry which can lead to improvements in aspects of their professional practices. This article challenges and extends conventional understanding of action
Bold, Christine +3 more
core
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source

