Results 251 to 260 of about 4,256,396 (290)

Immune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer. [PDF]

Clin Cancer Res
Yang DD, Abdelnaser A, Haas AJ, Wala J, Barney AA, Saad E, Crowdis JP, Ricker CA, Awad S, Gurel B, Park J, King MT, Nguyen PL, Choueiri TK, Einstein DJ, Balk SP, Tewari AK, de Bono JS, Salari K, Taplin ME, Wu CL, Van Allen EM.   +21 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

From "Old Man Yells at Cloud" to geronto-futurism: co-imagining holography and aging. [PDF]

Gerontologist
Schweigler S.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Core activation program and selective regional responsiveness of microglia during aging and parabiosis. [PDF]

Cell Rep
Naz H, Lu N, Escoubas CC, Sager L, Xiong J, Pálovics R, Yamada S, Molofsky AV, Wyss-Coray T, Li Q, Zhao G.   +10 more
europepmc   +1 more source

Complete chloroplast genome sequence and phylogenetic analysis of <i>Inula minipetala</i> Y.N. Lee ex H.B. Kim & D.C. Son (Asteraceae), an endemic Korean species. [PDF]

Mitochondrial DNA B Resour
Kim HB, Kang ES, Jang JE, Gil HY, Son DC.   +4 more
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis. [PDF]

Adv Sci (Weinh)
Liu Y, Liu S, Liang H, Yang J, Li Y, Yin J, Zhang X, Zhang Y, Bai D, Yan Z, Zhang Z, Jia Y, Liu K, Sheng Y, Xiang J, Xi C, Dong B, Lei X, Chen J, Wang H, Guo Y, Zhang Y, Gao S, Liu W.   +23 more
europepmc   +1 more source

CaMKIIβ Signaling drives expression of metabolic and stress response genes in skeletal muscle, and its loss contributes to the LGMDR1 phenotype. [PDF]

Hum Mol Genet
Kramerova I, Anastopulos F, Becerra D, Goldstein de Salazar R, Keeble AR, Chamberlain JS, Moore SA, McNally EM, Spencer MJ.   +8 more
europepmc   +1 more source