Results 251 to 260 of about 170,841 (292)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Increased complexity of social category markers leads to diverse rule-based categorizations and reduced intergroup bias. [PDF]

Proc Biol Sci
Hertz U.
europepmc   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Age-related differences in perceptual and mental imagery abilities. [PDF]

Front Psychol
Berardi AM.
europepmc   +1 more source

A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation. [PDF]

EMBO J
Xiang X, Gao A, Handler D, Falcon F, Rodriguez-Terrones D, Nowoshilow S, Liu W, Tanaka EM, O'Carroll D.   +8 more
europepmc   +1 more source

Intratumoral spatiotemporal heterogeneity of HPV DNA status in HPV-associated oropharyngeal squamous cell carcinoma with clinical record. [PDF]

J Transl Med
Ahn B, Park CW, Song JS, Lee HJ, Kim W, Lee YS, Jung YH, Choi SH, Nam SY, Kim SY, Oh JH, Kang YG, Oh DE, Sung CO, Cho KJ.   +14 more
europepmc   +1 more source

Mapping the research landscape of the correlation between radiotherapy and tumor immune microenvironment: A bibliometric analysis. [PDF]

Precis Radiat Oncol
Geng S, Li X, Dang Y, Huang X, Zhang L, He X, Pan S, Ma H, Zhao X.   +8 more
europepmc   +1 more source

Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation. [PDF]

Proc Natl Acad Sci U S A
Leong JY, McGovern N, Mishra A, Wasser M, Kumar P, Tay SH, Nur Hazirah S, Yeo JG, Tan XQ, Sutamam N, Azman FN, Chua CJH, Chen PZ, Ally F, Dutertre CA, Ramakrishna L, Poh SL, Xie L, Fan Y, Donner C, Papadopoulou M, Vermijlen D, Arkachaisri T, Chan JKY, Ginhoux F, Albani S.   +25 more
europepmc   +1 more source