Results 141 to 150 of about 14,755 (179)
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion. [PDF]
Nat GenetAboreden NG +7 more
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Neuropathy With Demyelinating Features in a Patient With Biallelic HARS1 Variants. [PDF]
J Peripher Nerv SystDel Greco C +5 more
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Smurf2 Regulates the Degradation of YY1
Biochimica Et Biophysica Acta - Molecular Cell Research, 2014 Transcription factor YY1 plays important roles in cell proliferation and differentiation. For example, YY1 represses the expression of muscle-specific genes and the degradation of YY1 is required for myocyte differentiation. The activity of YY1 can be regulated by various post-translational modifications; however, little is known about the regulatory ...
Chang-Yeol Yeo +2 more
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Modulation of YY1 Activity by SAP30
Biochemical and Biophysical Research Communications, 2003Yin Yang 1 (YY1) is a highly conserved and multifunctional transcription factor. The diverse activities of YY1 are regulated and sometimes modified by interaction with various other proteins. By using a yeast two-hybrid screening system, SAP30 was identified as a protein that associates with YY1 and it is able to enhance YY1-mediated repression in a ...
Young-Sun Lin, Winston C Y Yu
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Multifunctional YY1 in Liver Diseases
Seminars in Liver Disease, 2017AbstractThe transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the cellular context. While YY1 is ubiquitously expressed and highly conserved between species, its role varies among the diverse cell types and includes proliferation, differentiation, and apoptosis. Upregulated YY1
Mengjie, Zhang +9 more
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YY1 Is an Inducer of Cancer Metastasis
Critical Reviews™ in Oncogenesis, 2017Yin Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins that plays vital roles in many biological processes, especially tumorigenesis. To date, ample evidence suggests a critical regulatory role of YY1 in tumor cell metastasis. The potential of YY1 as a valuable biomarker for cancer metastasis has been increasingly known.
Wenmeng, Wang +2 more
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The Multilayered Regulation of the Oncogenic Protein YY1
Critical Reviews™ in Oncogenesis, 2017The multifunctional protein Yin Yang 1 (YY1) plays critical roles in tumorigenesis. YY1 has been shown to be involved in the development, progression, resistance, and invasiveness of many types of cancers. Today, the value of YY1 as a prognostic marker and as a potential target in cancer therapy is being explored by multiple research groups around the ...
Raed, Rizkallah, Myra M, Hurt
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Expression of YY1 in Differentiated Thyroid Cancer
Endocrine Pathology, 2015The transcription factor Yin Yang 1 (YY1) has an important regulatory role in tumorigenesis, but its implication in thyroid cancer has not been yet investigated. In the present study, we have analyzed the expression of YY1 in differentiated thyroid cancer and assessed the association of YY1 expression with clinical features.
Josep Castellvi +2 more
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YY1 in Cell Differentiation and Tissue Development
Critical Reviews™ in Oncogenesis, 2017Yin Yang1 (YY1) is a ubiquitous expressed transcription factor that modulates a variety of biologic processes with prominent roles in cellular differentiation and tissue development. Recent advances in molecular biology, mouse genetics, and particularly high-throughput sequencing have greatly enhanced our understanding of YY1 functions and underlying ...
Fengyuan, Chen +3 more
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