Results 151 to 160 of about 14,755 (179)

YY1 functions with INO80 to activate transcription

Nature Structural & Molecular Biology, 2007
Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires
Yong, Cai, Jingji, Jin, Tingting, Yao, Aaron J, Gottschalk, Selene K, Swanson, Su, Wu, Yang, Shi, Michael P, Washburn, Laurence, Florens, Ronald C, Conaway, Joan W, Conaway   +10 more
openaire   +2 more sources

YY1's Longer DNA-Binding Motifs

Genomics, 2009
The DNA-binding sites of YY1 located within two newly identified downstream genes of YY1, Peg3 (GGCGCCATnTT) and Xist (CCGCCATnTT), are longer than the known motif of YY1 (CGCCATnTT). Gel shift assays indicated that these DNA-binding sites are previously unnoticed, longer motifs of YY1.
Joomyeong Kim, Jeong Do Kim
exaly   +3 more sources

The roles of YY1 in reproductive system: an overview

Chemico-Biological Interactions
Yin Yang 1 (YY1) is a highly conserved multifunctional transcription factor with multiple biological functions including cell proliferation, differentiation and transcriptional regulation. In recent years, the discovery of the functional activity of YY1 in the reproductive tissues of animals, including humans has attracted more and more attention.
Yinan Wang, Songming He, Qin Huang, Jing Yang, Chaogang Yang, Jinli Ding   +5 more
openaire   +2 more sources

Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1

2019
Most human cancers respond poorly to conventional therapeutics, and those that respond develop resistance to subsequent treatments. It has been reported that in many, but not all, studied cancers, there exists a mini population of cancer stem cells (CSCs) that is highly drug resistant and that its survival leads to recurrences and metastases.
openaire   +1 more source

The Role of YY1 in Prostate Cancer

2009
Abstract : We conducted renalgraft experiments to study the role of YY1 in prostate cancer. We used the mouse prostate epithelial cells (MPECs) with either depleted endogenous YY1 or overexpressed exogenous YY1. The grafts of YY1-depleted MPECs did not show significant growth.
Scott D. Cramer, Guangchao Sui
openaire   +1 more source

NOVEL ROLES OF YY1 IN ASTROCYTES

2021
VCU Theses and ...
openaire   +1 more source

YY1 positively regulates human UBIAD1 expression

Biochemical and Biophysical Research Communications, 2015
Vitamin K is involved in bone formation and blood coagulation. Natural vitamin K compounds are composed of the plant form phylloquinone (vitamin K1) and a series of bacterial menaquionones (MK-n; vitamin K2). Menadione (vitamin K3) is an artificial vitamin K compound.
Nobuaki Funahashi, Yoshihisa Hirota, Kimie Nakagawa, Natumi Sawada, Masato Watanabe, Yoshitomo Suhara, Toshio Okano   +6 more
openaire   +2 more sources

Diagnostic and Prognostic roles of YY1

2010
Several investigators have observed YY1 deregulation in numerous tumor types. YY1 overexpression and its role in cancer were largely discussed during all of the workshop sessions. The results reported underlined the diagnostic and prognostic significance of YY1 in solid and hematologic malignancies.
LIBRA, Massimo, STIVALA F.
openaire   +1 more source

Chemotherapy resistance and YY1

2021
openaire   +1 more source

DeepYY1: A Deep Learning Approach to Identify YY1-Mediated Chromatin Loops.

Briefings in Bioinformatics, 2021
Fuying Dao, Hao Lin, Hao Lv
exaly