Results 91 to 100 of about 3,025,283 (308)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Z-scan applied to phosphate glasses doped with Er$^{3+}$-Yb$^{3+}$ and silver nanoparticles
, 2018 We report on the use of Z-scan technique with a beam composed with two modes, to probe the nonlinear optical properties of phosphate glasses doped with Er$^{3+}$-Yr$^{3+}$ and silver nanoparticles.
M. A. Martinez-Gamez (17496138) +6 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Implementing the SCAN language by neural networks
, 2010 The real-time encryption of pictures is an important subject for many applications, e.g. television broadcast stations, network security, etc. The paper shows how the previously introduced SCAN encryption method can be easily implemented using binary ...
Brause, Rüdiger W.
core
Plug & Test at System Level via Testable TLM Primitives [PDF]
, 2008 With the evolution of Electronic System Level (ESL) design methodologies, we are experiencing an extensive use of Transaction-Level Modeling (TLM). TLM is a high-level approach to modeling digital systems where details of the communication among modules ...
Navabi, Z. +12 more
core +1 more source
AIP Advances, 2020 Hybrid perovskites have been investigated for various potential applications because of their tunable optical properties. In this paper, we report the synthesis of quantum dots (QDs) of two-dimensional (2D) Ruddlesden–Popper (RP) hybrid perovskite using ...
Sreekanth J. Varma +5 more
doaj +1 more source
Polarization Z-Scan Studies Revealing Plasmon Coupling Enhancement Due to Dimer Formation of Gold Nanoparticles in Nematic Liquid Crystals. [PDF]
Micromachines (Basel), 2023 Wang S +3 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Lackstrukturmessung mit wave-scan DOI und Tastschnittverfahren
, 2022 Comparative measurements using the optical device wave-scan DOI and profilometry have been carried out on a clear coat wedge. A correlation between both measuring techniques could be found over a wide range of paint film structures.
Schneider, M.
core