Results 71 to 80 of about 3,025,283 (308)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Neither kerr nor thermal nonlinear response of dye doped liquid crystal characterized by the z-scan technique [PDF]
, 2008 In the experimental characterization of the nonlinear optical properties of dye-doped liquid crystals by the Z-scan technique with CW lasers it is rather common to assign it a Kerr or thermal nonlinear response.
CARLOS GERARDO TREVIÑO PALACIOS +3 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Influence of the photoinduced focal length of a thin nonlinear material in the Z-scan technique [PDF]
, 2007 In this paper the response purely refractive of a thin nonlinear material, in the z-scan technique experiment, is modeled as a lens with a focal length that is a function of some integer power of the incident beam radius.
CARLOS GERARDO TREVIÑO PALACIOS +4 more
core
Nonlinear Refraction of Gold Nanoparticles Suspended in Water [PDF]
Журнал нано- та електронної фізики, 2015 This paper presents the results of the experimental investigations of the surface plasmon resonances and nonlinear refraction of water suspensions of gold nanoparticles coated with a polymer shell.
R.V. Gamernyk +5 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Z-Scan And Ez-Scan Measurements Of Optical Nonlinearities
, 1994 We describe the application of single beam propagation methods, namely Z-scan and EZ-scan, for the determination of nonlinear refractive indices in materials including thin films.
core +1 more source