Results 1 to 10 of about 12,032 (129)

Novel ZAP-70-Related Immunodeficiency Presenting with Epstein–Barr Virus Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis [PDF]

Case Reports in Immunology, 2021
Zeta-chain-associated protein kinase 70 (ZAP-70) plays an integral role in the T-cell antigenic receptor complex. A deficiency of this kinase leads to a phenotype of severe combined immunodeficiency, while hypomorphic mutations of the kinase lead to more
Moriah Forster, Timothy Moran, Anne Beaven, Timothy Voorhees   +3 more
doaj   +4 more sources

ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies [PDF]

Frontiers in Oncology, 2020
Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation through its tyrosine kinase activity.
Jingyu Chen, Andrew Moore, Ingo Ringshausen   +2 more
doaj   +4 more sources

Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia [PDF]

BMC Research Notes, 2019
Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation.
Ameen Abdulaziz Basabaeen, Enaam Abdelrhman Abdelgader, Othman Saeed BaHashwan, Ebtihal Ahmed Babekir, Nour Mahmoud Abdelateif, Salem Ahmed Bamusa, Saadia Osman Abdelrahim, Osama Ali Altayeb, Eman Abbass Fadul, Ibrahim Khider Ibrahim   +9 more
doaj   +4 more sources

T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival. [PDF]

PLoS ONE, 2022
B-cell receptor (BCR) signalling is critical for the survival of B-cell lymphomas and is a therapeutic target of drugs such as Ibrutinib. However, the role of T-cell receptor (TCR) signalling in the survival of T/Natural Killer (NK) lymphomas is not ...
Sanjay de Mel, Nurulhuda Mustafa, Viknesvaran Selvarajan, Muhammad Irfan Azaman, Patrick William Jaynes, Shruthi Venguidessane, Hoang Mai Phuong, Zubaida Talal Alnaseri, The Phyu, Louis-Pierre Girard, Wee Joo Chng, Joanna Wardyn, Ying Li, Omer An, Henry Yang, Siok Bian Ng, Anand D Jeyasekharan   +16 more
doaj   +2 more sources

Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype [PDF]

BMC Pediatrics, 2023
Zeta(ζ)-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare autosomal recessive primary immunodeficiency disease. Little is known about this disease.
Xianze Luo, Qing Liu, Lina Zhou, Xuemei Tang, Xiaodong Zhao, Zhiyong Zhang   +5 more
doaj   +2 more sources

Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells [PDF]

Journal of Translational Medicine, 2010
Background ZAP-70 is an independent negative prognostic marker in chronic lymphocytic leukemia (CLL). Usually, its expression is investigated by flow cytometric protocols in which the percentage of ZAP-70 positive CLL cells is determined in respect to ...
Degan Massimo, Benedetti Dania, Fangazio Marco, Dal Bo Michele, Bomben Riccardo, Bulian Pietro, Zucchetto Antonella, Luciano Fabrizio, Irno Consalvo Maria, Rossi Davide, Del Principe Maria Ilaria, Rossi Francesca M, Gaidano Gianluca, Del Poeta Giovanni, Gattei Valter   +14 more
doaj   +2 more sources

Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review [PDF]

Frontiers in Immunology, 2020
Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) caused by recessive homozygous/compound heterozygous loss-of-function mutations in the ZAP70 gene.
Niusha Sharifinejad, Niusha Sharifinejad, Mahnaz Jamee, Mahnaz Jamee, Majid Zaki-Dizaji, Bernice Lo, Mohammadreza Shaghaghi, Mohammadreza Shaghaghi, Hamed Mohammadi, Hamed Mohammadi, Farhad Jadidi-Niaragh, Farhad Jadidi-Niaragh, Shiva Shaghaghi, Reza Yazdani, Hassan Abolhassani, Asghar Aghamohammadi, Gholamreza Azizi   +16 more
doaj   +2 more sources

Relationship Between ZAP-70 Gene (rs104893674 "A/C") Polymorphism With Risk for Acute Myeloid Leukemia [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2020
Background and Aim: In acute myeloid leukemia, a large number of immature cells develop, which can related to some single nucleotide polymorphisms presence in positions of  genes  that encodes enzymes involved in cell activation and evolution signaling ...
Masoomeh Rahimzadeh, Siroos Naeimi, Mohammad Mahdi Moghanibashi, Khalil Khashei Varnamkhasti   +3 more
doaj   +2 more sources

ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis [PDF]

Cells, 2019
T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the ...
Réka Kugyelka, Lilla Prenek, Katalin Olasz, Zoltán Kohl, Bálint Botz, Tibor T. Glant, Timea Berki, Ferenc Boldizsár   +7 more
doaj   +2 more sources

ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study [PDF]

Hematology, Transfusion and Cell Therapy, 2018
Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells ...
Rodolfo Patussi Correia, Flávia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo Pessini Amarante-Mendes   +5 more
doaj   +2 more sources