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Degradation mechanism for Zearalenone ring-cleavage by Zearalenone hydrolase RmZHD: A QM/MM study
Science of The Total Environment, 2020The danger of zearalenone (ZEN) as an endocrine disruptor to humans and the environment has aroused increasing attention. In this study, we implemented the quantum mechanics/molecular mechanics (QM/MM) method to investigate the degradation mechanism of ZEN hydrolase (RmZHD) toward ZEN at the atomic level.
Ledong Zhu +7 more
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Risk assessment of the mycotoxin zearalenone
Regulatory Toxicology and Pharmacology, 1987Trans-zearalenone, a resorcylic acid lactone, also known as F-2 toxin, is a nonsteroidal estrogenic mycotoxin produced by numerous species of Fusarium. As a result zearalenone is found in a number of cereal crops and their derived food products. A closely related substance "zeranol" (zearalanol) is at present being used in the United States and Canada ...
P.M. Scott +2 more
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Physiologically Based Pharmacokinetics of Zearalenone
Journal of Toxicology and Environmental Health, Part A, 2009The objectives of this study were to (1) develop physiologically based pharmacokinetic (PBPK) models for zearalenone following intravenous (i.v.) and oral (p.o.) dosing in rats and (2) predict concentrations in humans via interspecies scaling. The model for i.v.
Beom Soo Shin +10 more
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Determination of zearalenone and ochratoxin A in soil
Analytical and Bioanalytical Chemistry, 2003Mycotoxins are secondary metabolites, formed by the action of fungi on agricultural crops in the field or during storage. These metabolites are highly toxic to animals and humans and high levels have been measured in agricultural crops. In order to evaluate human risks due to ingestion of mycotoxin-contaminated food different methods have been ...
Mortensen, G. K. +2 more
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Journal of the American Oil Chemists' Society, 1979
AbstractZearalenone, a secondary metabolite with estrogenic properties, is produced by severalFusarium species that colonize cereal grains in the field and in storage. Recently, there have been reports of zearalenone contamination in corn, oats, barley, wheat, and grain sorghum. Corn and grain sorghum were examined for contamination due to obvious mold
O. L. Shotwell, G. A. Bennett
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AbstractZearalenone, a secondary metabolite with estrogenic properties, is produced by severalFusarium species that colonize cereal grains in the field and in storage. Recently, there have been reports of zearalenone contamination in corn, oats, barley, wheat, and grain sorghum. Corn and grain sorghum were examined for contamination due to obvious mold
O. L. Shotwell, G. A. Bennett
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Plasma and Urinary Levels of Zearalenone and α‐Zearalenol in a Prepubertal Gilt Fed Zearalenone
Acta Pharmacologica et Toxicologica, 1985One prepubertal gilt, fed 192 μg zearalenone/kg body weight/day for 4 days, showed plasma concentrations of α‐zearalenol 3–4 times higher than of the parent compound during the treatment. Zearalenone and α‐zearalenol could be traced in plasma until the 5th day and in urine until the 4th day of the posttreatment period.
K. Malmlöf +4 more
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Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone
Toxicon, 2015Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and β-cis-zearalenol using the E-Screen assay. Overall,
Martin Penkert +6 more
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1991
The mycotoxin zearalenone is known for its harmful effects on livestock reproduction. Animal exposure occurs through feed sources colonized by Fusarium species which produce the mycotoxin. Since regular screening procedures for zearalenone are not conducted on Western Canadian barley, a survey was carried out to test for possible significant levels of ...
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The mycotoxin zearalenone is known for its harmful effects on livestock reproduction. Animal exposure occurs through feed sources colonized by Fusarium species which produce the mycotoxin. Since regular screening procedures for zearalenone are not conducted on Western Canadian barley, a survey was carried out to test for possible significant levels of ...
openaire +2 more sources