Results 91 to 100 of about 419,255 (408)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Animal Models and Experimental Medicine, 2021 Stroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens.
Yanyu Li, Jingjing Zhang
doaj +1 more source
Understanding Neural Pathways in Zebrafish through Deep Learning and High Resolution Electron Microscope Data [PDF]
PEARC '18 Proceedings of the Practice and Experience on Advanced
Research Computing, Article No. 65, 2018, 2018 The tracing of neural pathways through large volumes of image data is an incredibly tedious and time-consuming process that significantly encumbers progress in neuroscience. We are exploring deep learning's potential to automate segmentation of high-resolution scanning electron microscope (SEM) image data to remove that barrier.
arxiv +1 more source
Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
core +2 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
4D blood flow mapping using SPIM-microPIV in the developing zebrafish heart [PDF]
Proc. SPIE 10499 (2018) 104991E, 2018 Fluid-structure interaction in the developing heart is an active area of research in developmental biology. However, investigation of heart dynamics is mostly limited to computational fluid dynamics simulations using heart wall structure information only, or single plane blood flow information - so there is a need for 3D + time resolved data to fully ...
arxiv +1 more source
A Single-Cell Transcriptome Atlas for Zebrafish Development
bioRxiv, 2019 The ability to define cell types and how they change during organogenesis is central to our understanding of animal development and human disease. Despite the crucial nature of this knowledge, we have yet to fully characterize all distinct cell types and
Dylan R. Farnsworth +2 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Molecules, 2021 Panax quinquefolius, a popular medicinal herb, has been cultivated in China for many years. In this work, the region-specific profiles of metabolites in P. quinquefolius from Wendeng was investigated using liquid-chromatography–quadrupole–time-of-flight-(
Xuanming Zhang +10 more
doaj +1 more source
An adaptively optimized algorithm for counting nuclei in X-ray micro-CT scans of whole organisms [PDF]
arXiv, 2021 Living organisms are primarily made of cells. Identifying them and characterizing their geometry and spatial distribution is a first step towards building multi-scale models of these biomaterials. We propose a method to count cells using nuclei in an X-ray microtomographic scan of a zebrafish. To account for scanning artifacts and partial volume effect,
arxiv