Results 71 to 80 of about 231,505 (286)
An in vivo study of signaling pathways involved in zebrafish thyroid formation. [PDF]
, 2013 The molecular pathways contributing to thyroid development and function appear to be highly conserved in vertebrates; similar to mammals, the zebrafish thyroid gland is composed of endoderm-derived follicles, filled with colloid and producing thyroid ...
G. Marchetto +16 more
core
Cellular and molecular studies of postembryonic muscle fibre recruitment in zebrafish (Danio rerio L.) [PDF]
, 2010 Cellular and molecular mechanisms of postembryonic muscle fibre recruitment were investigated in zebrafish (Danio rerio L.), a standard animal model for developmental and genetic studies.
Lee, Hung-Tai
core +2 more sources
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
The Scientific World Journal, 2006 We used the 500-bp Xenopusef1-α promoter and the 2-kb zebrafish histone 2A.F/Z promoter to generate several independent transgenic zebrafish lines expressing EGFP. While both promoters drive ubiquitous EGFP expression in early zebrafish development, they
Ryan Thummel +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration
Stem Cells International, 2015 The zebrafish is a useful animal model to study the signaling pathways that orchestrate kidney regeneration, as its renal nephrons are simple, yet they maintain the biological complexity inherent to that of higher vertebrate organisms including mammals ...
Kristen K. McCampbell +2 more
doaj +1 more source
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan +7 more
wiley +1 more source
Junctional complexes and cell-cell signalling in zebrafish morphogenesis [PDF]
, 2010 Intercellular junctions are composed of tight, gap and adherens junctions and have been shown to play many roles in embryonic morphogenesis. I have been studying the role that intercellular junctions play in zebrafish development.
Barker, D.J.
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Developmental ethanol exposure and its impact on behaviour and HPI axis activity of zebrafish [PDF]
, 2015 Ethanol exposure during pregnancy is one of the leading causes of preventable birth defects, leading to a range of symptoms collectively known as fetal alcohol spectrum disorder (FASD).
Baiamonte, Matteo
core +3 more sources
BMC GenomicsCongenital heart disease (CHD) is a prevalent condition characterized by defective heart development, causing premature death and stillbirths among infants.
Shikha Vashisht +2 more
doaj +1 more source