Results 51 to 60 of about 209,838 (313)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Ribosomal proteins in zebrafish haematopoiesis and human disease [PDF]
, 2011 PhDSeveral congenital disorders of human haematopoiesis including Diamond- Blackfan anaemia result from heterozygous loss of genes involved in ribosome biogenesis.
Payne, Elspeth
core
Effects of Holding Density on the Welfare of Zebrafish: A Systematic Review [PDF]
, 2021 The zebrafish is becoming an increasingly popular research animal around the world. Its welfare is affected by an array of environmental factors, such as food access and water quality.
Andersson, Marica, +1 more
core +1 more source
AnimalsBackground/Aims: The Mediterranean killifish, Aphanius fasciatus (Valenciennes, 1821), is a small euryhaline and eurytherm cyprinodont. While its ecology and role as a bioindicator are well known, its anatomy remains poorly understood.
Maria Cristina Guerrera +9 more
doaj +1 more source
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish
Cells, 2020 The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide ...
Blake Carrington +2 more
doaj +1 more source
N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway
Ecotoxicology and Environmental Safety, 2022 N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models, while the mechanisms involved were still not fully understood.
Saifang Fu +7 more
doaj +1 more source
The Zebrafish Sperm Proteome [PDF]
PROTEOMICSABSTRACT One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closely related species.
Jayme Cohen-Krais +9 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Exposure of zebrafish to brominated environmental chemicals [PDF]
, 2010 Fish reproduction and embryonic development may be sensitive to environmental chemicals. This thesis investigated effects of brominated flame retardants (BFRs) and polybrominated dibenzo-p-dioxins (PBDDs) on reproduction and early life-stage development ...
Norman Haldén, Anna
core
Spotlight on zebrafish:translational impact [PDF]
, 2014 In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. To showcase the translational impact of the model across multiple disease areas, Disease Models & Mechanisms has compiled a Special Issue that ...
Lalita Ramakrishnan +7 more
core +1 more source