Results 51 to 60 of about 317,987 (279)

BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish

Cells, 2020
The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide ...
Blake Carrington, Rachel N. Weinstein, Raman Sood   +2 more
doaj   +1 more source

Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography [PDF]

, 2007
Phase variance-based motion contrast is demonstrated using two phase analysis methods in a spectral domain optical coherence tomography system. Mobility contrast is demonstrated for an intensity matched Intralipid solution placed without flow within ...
Fingler, Jeff, Fraser, Scott E., Schwartz, Dan, Yang, Changhuei   +3 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Alimentary Tract Anatomy and Morphology in Early Adult Mediterranean Killifish Aphanius fasciatus (Valenciennes, 1821)

Animals
Background/Aims: The Mediterranean killifish, Aphanius fasciatus (Valenciennes, 1821), is a small euryhaline and eurytherm cyprinodont. While its ecology and role as a bioindicator are well known, its anatomy remains poorly understood.
Maria Cristina Guerrera, Lidia Pansera, Marialuisa Aragona, Kamel Mhalhel, Mauro Cavallaro, Maria Levanti, Rosaria Laurà, Giuseppe Montalbano, Francesco Abbate, Antonino Germanà   +9 more
doaj   +1 more source

Conserved and Divergent Features of Adult Neurogenesis in Zebrafish

Frontiers in Cell and Developmental Biology, 2020
Adult neurogenesis, i.e., the generation of neurons from neural stem cells (NSCs) in the adult brain, contributes to brain plasticity in all vertebrates.
Miriam Labusch, Miriam Labusch, Laure Mancini, Laure Mancini, David Morizet, David Morizet, Laure Bally-Cuif   +6 more
doaj   +1 more source

N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

Ecotoxicology and Environmental Safety, 2022
N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models, while the mechanisms involved were still not fully understood.
Saifang Fu, Rongbang Tan, Yufei Feng, Ping Yu, Yuqian Mo, Wei Xiao, Shouyu Wang, Jingjing Zhang   +7 more
doaj   +1 more source

Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation [PDF]

, 2017
Cell proliferation has generally been considered dispensable for anteroposterior extension of embryonic axis during vertebrate gastrulation. Signal transducer and activator of transcription 3 (Stat3), a conserved controller of cell proliferation ...
Liu, Yinzi, Sepich, Diane S, Solnica-Krezel, Lilianna   +2 more
core   +4 more sources

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives

Life
Central nervous system disorders represent a heterogeneous set of conditions triggered by genetic alterations, environmental exposures, infections, injuries, and even iatrogenic causes.
Lidia Pansera, Kamel Mhalhel, Mauro Cavallaro, Marialuisa Aragona, Rosaria Laurà, Maria Levanti, Maria Cristina Guerrera, Francesco Abbate, Antonino Germanà, Giuseppe Montalbano   +9 more
doaj   +1 more source

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis [PDF]

, 2017
Thyroid hormones (THs) are essential for embryonic brain development but the genetic mechanisms involved in the action of maternal THs (MTHs) are still largely unknown.
A Tallafuss, AC Lekven, AC Lekven, ALS Dowling, AP Halestrap, AV Gore, B Langmead, C Schuurmans, C Trapnell, CB Kimmel, CC Thompson, CM Armour, D Croft, D Lopez-Espindola, D Zada, DM Power, E Vrieze de, ECH Friesema, ECH Friesema, ECH Friesema, F Boukhtouche, F Chatonnet, F Chatonnet, F Supek, FJ Arjona, GD Vatine, GO Consortium, GR Williams, H Dong, H Gao, H Heuer, H Iwayama, J Bernal, J Chang, J Delbaere, J Jin, J Patel, J Schindelin, JJ Essner, JJ Essner, K Wallis, KR Holden, L Boccone, LA Desouza, MA Campinho, MA Campinho, MD Robinson, MF Batista, PC Holm, RB MacDonald, RS Dezonne, RT Zoeller, RT Zoeller, S Bertrand, S Horn, S Kersseboom, S Mayerl, S Skah, S-X Wu, T Pierfelice, VM Darras, VW Edward, Y Katsuyama, Y-C Cheng   +63 more
core   +2 more sources