Results 41 to 50 of about 209,207 (313)
AnimalsThis work provides a contribution to the understanding of the structure of the photophores in the mesopelagic fish Chauliodus sloani (family Stomiidae), which occasionally are stranded along the coasts of the Strait of Messina (Central Mediterranean Sea).
Mauro Cavallaro +9 more
doaj +1 more source
Circulation Research, 2010 During the last 10–15 years, the tiny, tropical, freshwater zebrafish has become one of the most powerful and versatile models for studying vertebrate heart development. Three recent reports in Nature remind us of just how much we owe to this fishy friend of research. The zebrafish was first developed for use as a model organism by George Streisinger
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Study of the role of the transcription factor Pax6b and different signaling pathways on pancreas differentiation in zebrafish (Danio rerio) [PDF]
, 2013 The developmental dynamics of the zebrafish pancreas are highly similar to mammals: the organ arises from a ventral and a dorsal bud (Field et al., 2003), and the endocrine compartment produces all different hormones: insulin, glucagon, somatostatin ...
B. Peers +12 more
core
Cug2 is essential for normal mitotic control and CNS development in zebrafish. [PDF]
, 2011 Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells.
H T Kim +25 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Modelling delta-notch perturbations during zebrafish somitogenesis
, 2013 The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, R. E. +8 more
core +1 more source
AnimalsBackground/Aims: The Mediterranean killifish, Aphanius fasciatus (Valenciennes, 1821), is a small euryhaline and eurytherm cyprinodont. While its ecology and role as a bioindicator are well known, its anatomy remains poorly understood.
Maria Cristina Guerrera +9 more
doaj +1 more source
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish
Cells, 2020 The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide ...
Blake Carrington +2 more
doaj +1 more source
N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway
Ecotoxicology and Environmental Safety, 2022 N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models, while the mechanisms involved were still not fully understood.
Saifang Fu +7 more
doaj +1 more source