Results 21 to 30 of about 104,138 (249)

Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift

open access: yesBMC Genomics, 2021
Background Liver fibrosis is a wound-healing response to tissue injury and inflammation hallmarked by the extracellular matrix (ECM) protein deposition in the liver parenchyma and tissue remodelling.
Maciej Migdał   +8 more
doaj   +1 more source

Zebrafish in oncology

open access: yesAging, 2013
Novel high-throughput technologies generate an unprecedented amount of data, which present a challenge for oncologists aiming to provide personalized treatment. Progress in genetic engineering and xenotransplantation in conjunction with live imaging could establish the zebrafish as one of the most versatile animal models for cancer research.
Barriuso, Jorge; id_orcid 0000-0002-5641-9105   +2 more
openaire   +2 more sources

Behaviour and morphology of the zebrafish, danio rerio [PDF]

open access: yes, 2001
Speciation remains a process that is poorly understood. In particular, little progress has been made in elucidating the mechanisms underlying prezygotic isolation. A full understanding requires a knowledge of underlying genetics.
Pritchard, Victoria Louise
core   +4 more sources

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

open access: yesBMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li   +4 more
doaj   +1 more source

Fluorescent PCR–based Screening Methods for Precise Knock-in of Small DNA Fragments and Point Mutations in Zebrafish

open access: yesBio-Protocol, 2023
Generation of zebrafish (Danio rerio) models with targeted insertion of epitope tags and point mutations is highly desirable for functional genomics and disease modeling studies.
Blake Carrington, Raman Sood
doaj   +1 more source

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish

open access: yesChinese Medicine, 2021
Background Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure.
Mengyan Hu   +8 more
doaj   +1 more source

Modelling Delta-Notch perturbations during zebrafish somitogenesis. [PDF]

open access: yes, 2013
The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, Ruth E.   +2 more
core   +1 more source

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

open access: yesFluids and Barriers of the CNS, 2022
Background Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood ...
Yanyu Li   +5 more
doaj   +1 more source

The toxicity of perfluoroalkyl acids in zebrafish (Danio rerio) [PDF]

open access: yes, 2013
Perfluoroalkyl acids (PFAAs) are globally distributed synthetic chemicals. Their unique properties make them widely used, in industry and elsewhere. These are a group of compounds with varying carbon chain lengths and functional groups.
Ul Haq, Mazhar
core   +1 more source

Ribosomal proteins in zebrafish haematopoiesis and human disease [PDF]

open access: yes, 2011
PhDSeveral congenital disorders of human haematopoiesis including Diamond- Blackfan anaemia result from heterozygous loss of genes involved in ribosome biogenesis.
Payne, Elspeth
core   +2 more sources

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