Results 21 to 30 of about 209,838 (313)

Zebrafish in oncology

Aging, 2013
Novel high-throughput technologies generate an unprecedented amount of data, which present a challenge for oncologists aiming to provide personalized treatment. Progress in genetic engineering and xenotransplantation in conjunction with live imaging could establish the zebrafish as one of the most versatile animal models for cancer research.
Barriuso, Jorge; id_orcid 0000-0002-5641-9105, Nagaraju, Raghavendar, Hurlstone, Adam; id_orcid 0000-0001-5260-9457   +2 more
openaire   +2 more sources

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

BMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li, Xiaoyu Li, Xunjie Ma, Wei Xiao, Jingjing Zhang   +4 more
doaj   +1 more source

Time for Zebrafish [PDF]

Frontiers in Integrative Neuroscience, 2011
A key challenge for identifying cellular bases of cognitive functions is to distinguish the contributions of different cell subtypes within complex circuits in a brain. Functional magnetic resonance imaging (fMRI) can reflect what brain areas are activated and electrophysiological recording can record neural activities adjacent to the electrodes, but ...
Ruey-Kuang eCheng, Suresh eJesuthasan, Suresh eJesuthasan, Suresh eJesuthasan, Trevor B Penney   +4 more
openaire   +3 more sources

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish

Chinese Medicine, 2021
Background Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure.
Mengyan Hu, Peirong Liu, Shuxian Lu, Zhihao Wang, Zhaojie Lyu, Hongkai Liu, Yuhong Sun, Feng Liu, Jing Tian   +8 more
doaj   +1 more source

Fluorescent PCR–based Screening Methods for Precise Knock-in of Small DNA Fragments and Point Mutations in Zebrafish

Bio-Protocol, 2023
Generation of zebrafish (Danio rerio) models with targeted insertion of epitope tags and point mutations is highly desirable for functional genomics and disease modeling studies.
Blake Carrington, Raman Sood
doaj   +1 more source

Modelling delta-notch perturbations during zebrafish somitogenesis [PDF]

, 2013
The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, R. E., Maini, P. K., Murray, PJ, Baker, RE, Baker, Ruth E., Murray, Philip J., Maini, PK, Murray, P J, Maini, Philip K.   +8 more
core   +2 more sources

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

Fluids and Barriers of the CNS, 2022
Background Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood ...
Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo, Jingjing Zhang   +5 more
doaj   +1 more source

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford, Crawford, Alexander D, Alexander I. Gray, Cordero-Maldonado, María Lorena, de Witte, Peter A M, Gray, Alexander I, Alan L Harvey, Camila V. Esguerra, Gebruers, Evelien, Evelien Gebruers, Harvey, Alan L, Carol Clements, Clements, Carol, Alexander D Crawford, Edrada-Ebel, Ruangelie, Camila V Esguerra, Alan L. Harvey, Ruangelie Edrada-Ebel, Esguerra, Camila V, María Lorena Cordero-Maldonado, Alexander I Gray, Peter A M de Witte, Cordero Maldonado, María Lorena, Peter A. M. de Witte   +23 more
core   +1 more source

Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism

Frontiers in Microbiology, 2023
Interventions to the gut microbiome manipulate the gut–brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium Paraburkholderia sabiae reduces anxiety-like behavior in
Shunsuke Ichikawa, Shunsuke Ichikawa, Reimi Abe, Haruka Fujimoto, Koushi Higashi, Liqing Zang, Liqing Zang, Hiroko Nakayama, Hiroko Nakayama, Izumi Matsuoka, Yasuhito Shimada, Yasuhito Shimada, Yasuhito Shimada   +12 more
doaj   +1 more source

The zebrafish organizer

Current Opinion in Genetics & Development, 1998
Signals from the organizer play a crucial role in patterning the vertebrate embryo. Recent molecular analysis of zebrafish mutations has established an essential role for BMP2 and chordin in organizer function and has identified one-eyed pinhead as a novel EGF-like gene involved in prechordal plate and endoderm formation.
A F, Schier, W S, Talbot
openaire   +2 more sources