Results 21 to 30 of about 209,207 (313)

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

BMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li, Xiaoyu Li, Xunjie Ma, Wei Xiao, Jingjing Zhang   +4 more
doaj   +1 more source

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish

Chinese Medicine, 2021
Background Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure.
Mengyan Hu, Peirong Liu, Shuxian Lu, Zhihao Wang, Zhaojie Lyu, Hongkai Liu, Yuhong Sun, Feng Liu, Jing Tian   +8 more
doaj   +1 more source

Fluorescent PCR–based Screening Methods for Precise Knock-in of Small DNA Fragments and Point Mutations in Zebrafish

Bio-Protocol, 2023
Generation of zebrafish (Danio rerio) models with targeted insertion of epitope tags and point mutations is highly desirable for functional genomics and disease modeling studies.
Blake Carrington, Raman Sood
doaj   +1 more source

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

Fluids and Barriers of the CNS, 2022
Background Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood ...
Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo, Jingjing Zhang   +5 more
doaj   +1 more source

Molecular psychiatry of zebrafish

, 2014
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry.
Parker, M. O., Stewart, AM, Stewart, A. M., Stewart, A. M ., Ullmann, J. F. P., Norton, WHJ, Ullmann, JFP, Kalueff, A. V., Gerlai, R, Norton, W. H. J., Brennan, C. H., Gerlai, R., Brennan, CH, Parker, MO, Kalueff, AV   +14 more
core   +1 more source

Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism

Frontiers in Microbiology, 2023
Interventions to the gut microbiome manipulate the gut–brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium Paraburkholderia sabiae reduces anxiety-like behavior in
Shunsuke Ichikawa, Shunsuke Ichikawa, Reimi Abe, Haruka Fujimoto, Koushi Higashi, Liqing Zang, Liqing Zang, Hiroko Nakayama, Hiroko Nakayama, Izumi Matsuoka, Yasuhito Shimada, Yasuhito Shimada, Yasuhito Shimada   +12 more
doaj   +1 more source

The zebrafish organizer

Current Opinion in Genetics & Development, 1998
Signals from the organizer play a crucial role in patterning the vertebrate embryo. Recent molecular analysis of zebrafish mutations has established an essential role for BMP2 and chordin in organizer function and has identified one-eyed pinhead as a novel EGF-like gene involved in prechordal plate and endoderm formation.
A F, Schier, W S, Talbot
openaire   +2 more sources

Perspectives in Zebrafish Research

, 2020
In the past decade, a small tropical vertebrate fish, zebrafish, has rapidly gained the interest of research laboratories worldwide as a model system. This topic will provide updated perspectives on all fields of zebrafish research from experts gathering

core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations

Nature Communications
In the adult brain, Notch3 signaling promotes neural stem cell (NSC) quiescence and stemness. It remains unknown how Notch3 signaling levels are controlled and relate to these NSC decisions.
Sara Ortica, Miguel Martinez Herrera, Louis Degroux, Bastian Rochette, Nicolas Dray, Laure Bally-Cuif   +5 more
doaj   +1 more source