Results 11 to 20 of about 104,138 (249)
A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]
, 2013 Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Crawford, Alexander D +8 more
core +3 more sources
Zebrafish and Flavonoids: Adjuvants against Obesity
Molecules, 2021 Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic ...
Giuseppe Montalbano +8 more
doaj +1 more source
Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery
Molecular Medicine, 2017 Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip +8 more
doaj +1 more source
Frontiers in Integrative Neuroscience, 2011 A key challenge for identifying cellular bases of cognitive functions is to distinguish the contributions of different cell subtypes within complex circuits in a brain. Functional magnetic resonance imaging (fMRI) can reflect what brain areas are activated and electrophysiological recording can record neural activities adjacent to the electrodes, but ...
Ruey-Kuang eCheng +4 more
openaire +3 more sources
Molecular psychiatry of zebrafish [PDF]
, 2014 Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry.
Parker, M. O. +14 more
core +1 more source
The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function [PDF]
, 2013 Zebrafish have great potential to contribute to our understanding of behavioural genetics and thus to contribute to our understanding of the aetiology of psychiatric disease.
Brock, AJ +15 more
core +1 more source
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish
Animal Cells and Systems, 2023 Puromycin treatment can cause glomerular injury to the kidney, leading to proteinuria. However, the pathogenesis of acute kidney injury and subsequent regeneration after puromycin administration in animal models remain unclear.
Soonil Koun +5 more
doaj +1 more source
Development and automation of a test of impulse control in zebrafish [PDF]
, 2013 Deficits in impulse control (difficulties in inhibition of a pre-potent response) are fundamental to a number of psychiatric disorders, but the molecular and cellular basis is poorly understood.
Straw, C +27 more
core +1 more source
Zebra-Fishing for Regenerative Awakening in Mammals
Biomedicines, 2021 Regeneration is defined as the ability to regrow an organ or a tissue destroyed by degeneration or injury. Many human degenerative diseases and pathologies, currently incurable, could be cured if functional tissues or cells could be restored ...
Laura Massoz +2 more
doaj +1 more source
Magnetosensation in zebrafish [PDF]
Current Biology, 2005 AbstractMany species, from bacteria to vertebrates, have been reported to use the geomagnetic field as a major cue for oriented short and long range migration [1–10], but the molecular nature of the underlying receptor has remained elusive. One of the main reasons may be that past attempts to train animals to respond to magnetic stimuli proved ...
Shcherbakov, Denis +5 more
openaire +2 more sources