Results 91 to 100 of about 209,838 (313)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Developmental ethanol exposure and its impact on behaviour and HPI axis activity of zebrafish [PDF]

, 2015
Ethanol exposure during pregnancy is one of the leading causes of preventable birth defects, leading to a range of symptoms collectively known as fetal alcohol spectrum disorder (FASD).
Baiamonte, Matteo
core  

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Zebrafish mitofusin-2 knockdown: a new model for CMT2A neuropathy? [PDF]

, 2009
Mitofusin 2 (MFN2) is a large dynamin-like GTPase protein, located in the outer membrane of mitochondria and at the surface of the endoplasmic reticulum.
VETTORI, ANDREA, ARGENTON, FRANCESCO, TISO, NATASCIA, MOSTACCIUOLO, MARIA LUISA, VAZZA, GIOVANNI, POLO G, BERGAMIN, GIORGIA, MORO, ENRICO   +7 more
core  

Dynamic cell rearrangements shape the cranial vascular network of developing Zebrafish embryos [PDF]

, 2013
To form the complex network of endothelial tubes making up the vasculature, a number of vessels have to interact and connect to each other during development.
Lenard, Anna
core   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

ia2 mutant: a zebrafish model of spontaneous pancreatic carcinomas and soft-tissue sarcomas [PDF]

, 2013
Pancreatic adenocarcinoma is one of the most lethal of human malignancies, and, despite the advances in the understanding of the molecular events responsible for its progression, ultimate therapeutic options are lacking.
A. Domenichini, VETTORI, ANDREA, ARGENTON, FRANCESCO, TISO, NATASCIA, RUGGE, MASSIMO, M. Astone, M. Pizzi, S. Tochterle, D. Meyer   +8 more
core  

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]

, 2013
The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn, Rothman, A.M.K., Gray, Caroline, Haase, A., Haase, Andrea, Novodvorsky, P., Rothman, Alexander M K, Van Eeden, Fredericus J. M., Gering, Martin, Crossman, D.C., Chico, Timothy J. A., Watson, O., Crossman, David C, Chico, Timothy J A, Gering, M., Rothman, Alexander M. K., Crossman, David C., Novodvorsky, Peter, Lawrie, A., McMahon, K., Van Eeden, Fredericus J M, Lawrie, Allan, Van Eeden, F.J.M., Chico, T.J.A., Watson, Oliver, Gray, C.   +25 more
core   +1 more source

A spatiotemporal atlas of cerebrovascular development in zebrafish

Nature Communications
The vertebrate brain requires precisely patterned vasculature, yet the molecular and cellular dynamics of cerebrovascular development remain incompletely understood. While single-cell studies have profiled brain vasculature, integrating these data across
Xiaoyu Li, Shanshan Ke, Chengchao Wu, Mei Wu, Yunfei Ren, Zitong Wang, Jialan Tang, Yuying Zheng, Da Mi, Jingjing Zhang   +9 more
doaj   +1 more source

Waveguide Photoactuators: Materials, Fabrication, and Applications

Advanced Robotics Research, EarlyView.
Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi, Hemin Pan, Yang Zong, Yongfeng Mei, Jizhai Cui   +4 more
wiley   +1 more source