Results 101 to 110 of about 209,838 (313)

Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development

Frontiers in Cellular Neuroscience
IntroductionAngiopoietin 1 (angpt1) is essential for angiogenesis. However, its role in neurogenesis is largely undiscovered. This study aimed to identify the role of angpt1 in brain development, the mode of action of angpt1, and its prime targets in the
Yu-Chia Chen, Yu-Chia Chen, Tomás A. Martins, Tomás A. Martins, Valentina Marchica, Valentina Marchica, Pertti Panula, Pertti Panula   +7 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Effects of UV filters (benzophenones and octocrylene) and mifepristone on different life stages of zebrafish (Danio rerio) [PDF]

, 2014
This thesis addresses effects of personal care products (PPCPs) and pharmaceuticals to zebrafish (Danio rerio). Personal care products including cosmetics and sunscreens are used for human welfare and contain organic UV absorbing chemicals, so-called UV ...
Blüthgen, Nancy
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, Usp9 [PDF]

, 2007
Copyright © 2007 Mary Ann Liebert, Inc.Mouse Usp9x/Fam (fat facets in mouse) and its Drosophila ortholog faf (fat facets) encode substrate-specific deubiquitylating enzymes and are essential for early embryonic development. The zebrafish (Danio rerio) is
Khut, P., Lardelli, M., Khut, Poon-Yu, Tucker, B., Wood, S., Wood, Stephen A, Tucker, Ben, Lardelli, Michael, A. Wood, Stephen   +8 more
core   +1 more source

αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish

Cell Reports, 2019
Summary: The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan.
Ajeet Pratap Singh, Maria X. Sosa, Jian Fang, Shiva Kumar Shanmukhappa, Alexis Hubaud, Caroline H. Fawcett, Gregory J. Molind, Tingwei Tsai, Paola Capodieci, Kristie Wetzel, Ellen Sanchez, Guangliang Wang, Matthew Coble, Wenlong Tang, Samuel M. Cadena, Mark C. Fishman, David J. Glass   +16 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Behaviour and morphology of the zebrafish, danio rerio [PDF]

, 2001
Speciation remains a process that is poorly understood. In particular, little progress has been made in elucidating the mechanisms underlying prezygotic isolation. A full understanding requires a knowledge of underlying genetics.
Pritchard, Victoria Louise
core  

The hybrid history of zebrafish

G3: Genes, Genomes, Genetics
Abstract Since the description of zebrafish (Danio rerio) in 1822, the identity of its closest living relative has been unclear. To address this problem, we sequenced the exomes of 10 species in genus Danio, using the closely related Devario aequipinnatus as outgroup, to infer relationships across the 25 chromosomes of the zebrafish ...
Braedan M. McCluskey, Peter Batzel, John H. Postlethwait   +2 more
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source