Results 121 to 130 of about 209,838 (313)

Whole-body imaging of a hypercholesterolemic female zebrafish by using synchrotron x-ray micro-CT [PDF]

, 2018
Zebrafish has been used as a powerful model system in biological and biomedical studies studying development and diseases. Comparative, functional, and developmental studies on zebrafish morphology require precise visualization of 3D morphological ...
Seo, E, Lee, SJ, Seo, SJ, Lim, JH
core   +1 more source

Cannabinoid Receptor 1 Regulates Zebrafish Renal Multiciliated Cell Development via cAMP Signaling

Journal of Developmental Biology
Endocannabinoid signaling plays a significant role in neurogenesis and nervous system physiology, but its roles in the development of other tissues are just beginning to be appreciated.
Thanh Khoa Nguyen, Sophia Baker, Julienne Angtuaco, Liana Arceri, Samuel Kaczor, Bram Fitzsimonds, Matthew R. Hawkins, Rebecca A. Wingert   +7 more
doaj   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage [PDF]

, 2014
In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes ...
Cheng, Chien-Chung; Chen, Yau-Hung, Cheng, Chien-Chung; Chou, Chi-Yuan; Chang, Yao-Chin; Wang, Hsuan-Wen; Wen, Chi-Chung; Chen, Yau-Hung   +1 more
core   +1 more source

Mathematical modeling reveals cell differentiation processes and progenitor kinetics necessary for proper nephrogenesis

Frontiers in Cell and Developmental Biology
IntroductionThe developing zebrafish nephron contains a diverse repertoire of cell populations with intrinsically dynamic roles and interactions. Previous studies characterizing these populations have utilized genetic approaches based on powerful ...
Matthew R. Hawkins, Stuart E. Jones, Hannah M. Wesselman, Cecilia Cesa, Joshua Moeller, Rebecca A. Wingert   +5 more
doaj   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Microbial polyunsaturated fatty acids (PUFAs) for human health: A comprehensive review of evidence from in vivo preclinical models

Discover Applied Sciences
Polyunsaturated fatty acids (PUFAs), including C18 PUFAs (linoleic [LA] and α-linolenic [ALA] acids) and their longer-chain derivatives (LC-PUFAs such as arachidonic [AA], eicosapentaenoic [EPA], and docosahexaenoic [DHA] acids), are essential nutrients ...
Sourik Mukherjee, Aman Kumar Mohanty, Uma Rao, Abhijit Poddar   +3 more
doaj   +1 more source

The Visual Systems of Zebrafish

Annual Review of Neuroscience
The zebrafish visual system has become a paradigmatic preparation for behavioral and systems neuroscience. Around 40 types of retinal ganglion cells (RGCs) serve as matched filters for stimulus features, including light, optic flow, prey, and objects on a collision course.
Baier, H. ; https://orcid.org/0000-0002-7268-0469, Scott, E.   +1 more
openaire   +5 more sources

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source