Results 131 to 140 of about 209,207 (313)

Two Small Peptides from Buthus martensii Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways

Life
The scorpion Buthus martensii Karsch is edible and has been an essential resource in traditional Chinese medicine for treating numerous diseases. In this study, two small peptides from B.
Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin   +7 more
doaj   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

TnP as a Multifaceted Therapeutic Peptide with System-Wide Regulatory Capacity

Pharmaceuticals
Background: The candidate therapeutic peptide TnP demonstrates broad, system-level regulatory capacity, revealed through integrated network analysis from transcriptomic data in zebrafish.
Geonildo Rodrigo Disner, Emma Wincent, Carla Lima, Monica Lopes-Ferreira   +3 more
doaj   +1 more source

Zebrafish stamps [PDF]

Lab Animal, 2019
openaire   +2 more sources

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source

Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, Usp9

, 2007
Copyright © 2007 Mary Ann Liebert, Inc.Mouse Usp9x/Fam (fat facets in mouse) and its Drosophila ortholog faf (fat facets) encode substrate-specific deubiquitylating enzymes and are essential for early embryonic development. The zebrafish (Danio rerio) is
Khut, P., Lardelli, M., Khut, Poon-Yu, Tucker, B., Wood, S., Wood, Stephen A, Tucker, Ben, Lardelli, Michael, A. Wood, Stephen   +8 more
core   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, EarlyView.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

Histological Assessment of Intestinal Changes Induced by Liquid Whey-Enriched Diets in Pigs

Veterinary Sciences
Liquid whey (LW) is a nutrient-rich dairy by-product and a promising resource for animal nutrition. However, data regarding its impact on intestinal morphology and endocrine signaling are limited.
Kamel Mhalhel, Mauro Cavallaro, Lidia Pansera, Leyanis Herrera Ledesma, Maria Levanti, Antonino Germanà, Anna Maria Sutera, Giuseppe Tardiolo, Alessandro Zumbo, Marialuisa Aragona, Giuseppe Montalbano   +10 more
doaj   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source