Results 151 to 160 of about 419,255 (408)

N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

Ecotoxicology and Environmental Safety, 2022
N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models, while the mechanisms involved were still not fully understood.
Saifang Fu, Rongbang Tan, Yufei Feng, Ping Yu, Yuqian Mo, Wei Xiao, Shouyu Wang, Jingjing Zhang   +7 more
doaj  

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

Nature, 2016
The maternal-to-zygotic transition (MZT) is one of the most profound and tightly orchestrated processes during the early life of embryos, yet factors that shape the temporal pattern of vertebrate MZT are largely unknown.
B. Zhao, Xiao Wang, Alana V. Beadell, Zhike Lu, Hailing Shi, Adam Kuuspalu, R. Ho, Chuan He   +7 more
semanticscholar   +1 more source

Investigating the Role of FGF8 Signaling in Neurogenesis of the Developing Zebrafish Eye [PDF]

, 2015
In the embryonic zebrafish, the fibroblast growth factor 8a (FGF8) signaling network is essential for proper development and maintenance of retinal ganglion cells (RGCs) as well as the hyaloid vasculature, the vessels that supply the eye with nutrients ...
Flinn, Benjamin A
core   +1 more source

A novel behavioral fish model of nociception for testing analgesics [PDF]

, 2011
Pain is a major symptom in many medical conditions, and often interferes significantly with a person's quality of life. Although a priority topic in medical research for many years, there are still few analgesic drugs approved for clinical use.
Ana D. Correia, Ashley, Barrallo, Bowman, Braithwaite, Breivik, Breivik, Brunner, Chervova, Chervova, Chervova, Cunha, Dunlop, E. Don Stevens, Ehrensing, Friend, Gonzalez-Nunez, Herrero-Turrion, Le Bars, Mansour, Martin Scholze, Matthes, Newby, Newby, Newby, Nordgreen, Nordgreen, Reilly, Ribeiro, Ribeiro, Sanchez-Simon, Sneddon, Sneddon, Sneddon, Sneddon, Sneddon, Stevens, Stevens, Sérgio R. Cunha, Tukey, Wheeler-Aceto, Zon   +41 more
core   +3 more sources

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Microbial polyunsaturated fatty acids (PUFAs) for human health: A comprehensive review of evidence from in vivo preclinical models

Discover Applied Sciences
Polyunsaturated fatty acids (PUFAs), including C18 PUFAs (linoleic [LA] and α-linolenic [ALA] acids) and their longer-chain derivatives (LC-PUFAs such as arachidonic [AA], eicosapentaenoic [EPA], and docosahexaenoic [DHA] acids), are essential nutrients ...
Sourik Mukherjee, Aman Kumar Mohanty, Uma Rao, Abhijit Poddar   +3 more
doaj   +1 more source

Peering through zebrafish to understand inherited bone marrow failure syndromes

Haematologica, 2018
Inherited bone marrow failure syndromes are experiments of nature characterized by impaired hematopoiesis with cancer and leukemia predisposition. The mutations associated with inherited bone marrow failure syndromes affect fundamental cellular pathways,
Usua Oyarbide, J. Topczewski, S. Corey
semanticscholar   +1 more source

scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

Advanced Science, EarlyView.
scCompass integrates and standardizes transcriptomic data from ≈105 million single cells across 13 species, enabling the identification of stable expression genes and organ‐specific expression genes in humans and mice. It provides scalable datasets for AI model training, pretrained model checkpoints, and user‐friendly platforms for data sharing ...
Pengfei Wang, Wenhao Liu, Jiajia Wang, Yana Liu, Pengjiang Li, Ping Xu, Wentao Cui, Ran Zhang, Qingqing Long, Zhilong Hu, Chen Fang, Jingxi Dong, Chunyang Zhang, Yan Chen, Chengrui Wang, Guole Liu, Hanyu Xie, Yiyang Zhang, Meng Xiao, Shubai Chen, Haiping Jiang, The X‐Compass Consortium, Yiqiang Chen, Ge Yang, Shihua Zhang, Zhen Meng, Xuezhi Wang, Guihai Feng, Xin Li, Yuanchun Zhou   +29 more
wiley   +1 more source

Two Small Peptides from Buthus martensii Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways

Life
The scorpion Buthus martensii Karsch is edible and has been an essential resource in traditional Chinese medicine for treating numerous diseases. In this study, two small peptides from B.
Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin   +7 more
doaj   +1 more source

Developmental Effects and Estrogenicity of Bisphenol A Alternatives in a Zebrafish Embryo Model.

Environmental Science and Technology, 2018
In order to understand the negative effects of bisphenol A (BPA) alternatives comprehensively, zebrafish embryos were used to assess the lethality, developmental effects, and estrogenic activity of bisphenol analogues. The in silico estrogenic activities
Xiyan Mu, Ying Huang, Xuxing Li, Yunlei Lei, Miaomiao Teng, Xuefeng Li, Chengju Wang, Yingren Li   +7 more
semanticscholar   +1 more source