Results 21 to 30 of about 367,304 (292)

Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis [PDF]

, 2011
Background\ud DNA methylation is an epigenetic mechanism associated with regulation of gene expression and it is modulated during chemical carcinogenesis.
Chipman, J Kevin, Gong, Zhiyuan, Mirbahai, Leda, Williams, Timothy D, Zhan, Huiqing   +4 more
core   +4 more sources

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

BMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li, Xiaoyu Li, Xunjie Ma, Wei Xiao, Jingjing Zhang   +4 more
doaj   +1 more source

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish

Chinese Medicine, 2021
Background Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure.
Mengyan Hu, Peirong Liu, Shuxian Lu, Zhihao Wang, Zhaojie Lyu, Hongkai Liu, Yuhong Sun, Feng Liu, Jing Tian   +8 more
doaj   +1 more source

A colour preference technique to evaluate acrylamide-induced toxicity in zebrafish [PDF]

, 2017
The zebrafish has become a commonly used vertebrate model for toxicity assessment, of particular relevance to the study of toxic effects on the visual system because of the structural similarities shared by zebrafish and human retinae. In this article we
Albalawi, Aishah, Jia, Laibing, Raghupathy, Rakesh Kotapati, Reilly, James, Shu, Xinhua, Xiao, Qing, Zhao, Zhenkai   +6 more
core   +3 more sources

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

Fluids and Barriers of the CNS, 2022
Background Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood ...
Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo, Jingjing Zhang   +5 more
doaj   +1 more source

Fluorescent PCR–based Screening Methods for Precise Knock-in of Small DNA Fragments and Point Mutations in Zebrafish

Bio-Protocol, 2023
Generation of zebrafish (Danio rerio) models with targeted insertion of epitope tags and point mutations is highly desirable for functional genomics and disease modeling studies.
Blake Carrington, Raman Sood
doaj   +1 more source

New zebrafish models of neurodegeneration [PDF]

, 2015
In modern biomedicine, the increasing need to develop experimental models to further our understanding of disease conditions and delineate innovative treatments has found in the zebrafish (Danio rerio) an experimental model, and indeed a valuable asset ...
A Nasevicius, A Vaccaro, AE Schaffer, AJ Rennekamp, AM Stewart, B Schmid, Claire Russell, DI Shah, EM Caramillo, F Ivanes, F Mahmood, HQ Jiang, JB Phillips, JW Mink, K Wager, K Wager, KC Donnell, KL Cerveny, L Wang, M Bond, M Nguyen, Michelangelo Campanella, MK Lin, PR Kasher, Rebeca Martín-Jiménez, S Ajroud-Driss, TO Auer, VT Cunliffe, Y Namavar   +28 more
core   +2 more sources

Calsequestrins in skeletal and cardiac muscle from adult Danio rerio [PDF]

, 2015
Calsequestrin (Casq) is a high capacity, low affinity Ca2+-binding protein, critical for Ca2+-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms.
Argenton, Francesco, Furlan, Sandra, Mosole, Simone, Murgia, Marta, Nagaraj, Nagarjuna, Nori, Alessandra, Volpe, Pompeo   +6 more
core   +1 more source

A Zebrafish Model of Mycobacterium leprae Granulomatous Infection. [PDF]

, 2017
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at approximately 30°C, so we sought to model granulomatous disease in
Cameron, James, Madigan, Cressida A, Ramakrishnan, Lalita   +2 more
core   +2 more sources

Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism

Frontiers in Microbiology, 2023
Interventions to the gut microbiome manipulate the gut–brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium Paraburkholderia sabiae reduces anxiety-like behavior in
Shunsuke Ichikawa, Shunsuke Ichikawa, Reimi Abe, Haruka Fujimoto, Koushi Higashi, Liqing Zang, Liqing Zang, Hiroko Nakayama, Hiroko Nakayama, Izumi Matsuoka, Yasuhito Shimada, Yasuhito Shimada, Yasuhito Shimada   +12 more
doaj   +1 more source