Results 91 to 100 of about 2,775,940 (306)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
On the zeros of sequences of polynomials
Journal of Approximation Theory, 1990 The author presents a generalization of Blatt, Staff and Simkani theorem on the limit distribution of zeros of sequences of polynomials. The advantage of the generalized theorem lies in the fact that it does not mention the highest coefficient of the polynomials.
openaire +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Zero sequence behaviour of a double-circuit overhead line
, 2014 tPositive, negative and zero sequence series impedances (in /km units) are the first step for power flowand short circuit analyses and are also necessary for setting the distance relays.
DAMBONE SESSA, SEBASTIAN +6 more
core +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
A Stopping Game on Zero-Sum Sequences
We introduce and analyze a natural game formulated as follows. In this one-person game, the player is given a random permutation $A=(a_1,\dots, a_n)$ of a multiset $M$ of $n$ reals that sum up to $0$, where each of the $n!$ permutation sequences is equally likely. The player only knows the value of $n$ beforehand.
Adrian Dumitrescu, Arsenii Sagdeev
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FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Subsequence Sums of Zero-sum-free Sequences [PDF]
The Electronic Journal of Combinatorics, 2009 Let $G$ be a finite abelian group, and let $S$ be a sequence of elements in $G$. Let $f(S)$ denote the number of elements in $G$ which can be expressed as the sum over a nonempty subsequence of $S$. In this paper, we slightly improve some results of Pixton on $f(S)$ and we show that for every zero-sum-free sequences $S$ over $G$ of length $|S|=\exp(G ...
openaire +2 more sources