Results 71 to 80 of about 2,048,363 (280)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Three‐phase isolated power transformer based novel structure for power distribution system and new theoretical/practical judgement criteria in detecting high‐impedance earth faults

IET Renewable Power Generation, 2023
Single phase‐earth faults are the most frequent faults likely to occur but hard to identify in distribution system, especially in a neutral un‐effectively grounded system.
Hua Zhang, Xueneng Su, Longjiang Li, Xin Ning, Rui Zhang, Cheng Long, Shilong Li, Yiwen Gao   +7 more
doaj   +1 more source

Molecular recognition by van der Waals interaction between polymers with sequence-specific polarizabilities

, 2015
We analyze van der Waals interactions between two rigid polymers with sequence-specific, anisotropic polarizabilities along the polymer backbones, so that the dipole moments fluctuate parallel to the polymer backbones.
Lu, Bing-Sui, Naji, Ali, Podgornik, Rudolf   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

High-impedance faulty feeder detection for cross-country faults in distribution networks based on zero-sequence active power regulation

International Journal of Electrical Power & Energy Systems
The weak characteristics of high-impedance faults and the complex attributes of cross-country faults make faulty feeder detection of cross-country high-impedance faults difficult in medium-voltage networks. This paper deduces the zero-sequence equivalent
Yuting Lan, Kun Yu, Xiangjun Zeng, Rong Cai, Qingbo Deng, Chenyu Wu, Shigeng He, Shijie Xu, Youcheng Jia   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research of Fault Line Selection Method of Distribution Network Based on Transient Zero-sequence Energy

Gong-kuang zidonghua, 2012
For problem of ineffectiveness of traditional line selection methods by use of single feature value caused by complex and random fault borderline, small steady component of fault and reverse phase of instantaneous zero-sequence power when single-phase ...
TIAN Shu, HE Jin-peng, NIE He
doaj  

Method of damping nutation motion with minimum spin axis attitude disturbance [PDF]

, 1983
In a method of and apparatus for damping nutation of a spinning spacecraft, spin axis attitude disturbances are substantially reduced by controlling at least one nutation damping gas thruster to fire with nonuniform gas pulses.
Hoffman, H. C.
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source